Coming to light: the transcriptional regulatory roles of histone lysine crotonylation in health and disease [0.03%]
见光发亮：组蛋白赖氨酸巴豆酰化在健康和疾病中的转录调控作用
Shang-Kun Dai,Naixia Ren,Chang-Mei Liu et al.
Shang-Kun Dai et al.
Research on histone lysine crotonylation has evolved from identifying its core regulatory factors and mapping its genome-wide landscape to dissecting its functions in physiological and pathological contexts. Since its discovery nearly 15 ye...
Implications of ferritinophagy in cardiovascular diseases and its pharmacological modulation: underlying mechanisms and clinical translation strategies [0.03%]
铁蛋白自噬在心血管疾病中的意义及其药理学调节：潜在机制和临床转化策略
Yan-Lin Wu,Ling Xiao,He-Ning Li et al.
Yan-Lin Wu et al.
Ferritinophagy is a crucial intracellular process mediated by the selective autophagy receptor nuclear receptor coactivator 4 (NCOA4), which plays a central role in maintaining iron homeostasis by regulating ferritin degradation. In recent ...
NAT10-mediated ac4C modification of TNFRSF1A promotes acute kidney injury by activating NF-κB pathway [0.03%]
NAT10介导的TNFRSF1A上的ac4C修饰通过激活NF-κB途径促进急性肾脏损伤
Minjie Zhang,Yankun Li,Chunyu Wu et al.
Minjie Zhang et al.
Background: Acute kidney injury (AKI) is closely linked to inflammatory responses driven by the NF-κB pathway, yet the epigenetic mechanisms underlying this association remain poorly understood. This study investigates t...
Rv1983 promotes mycobacterial dissemination by triggering ferroptosis through GPX4 ubiquitination [0.03%]
Rv1983通过GPX4泛素化诱导铁死亡促进分枝杆菌扩散
Zilu Qu,Yuanyuan Zhou,Qinzhen Cai et al.
Zilu Qu et al.
Background: Ferroptosis, a unique form of regulated cell death induced by iron-dependent lipid peroxidation, has been implicated in the pathogenesis of Mycobacterium tuberculosis (Mtb). However, the role of Mtb proteins, ...
RING finger E3 ubiquitin ligases: novel therapeutic opportunities in melanoma [0.03%]
新型泛素连接酶(RING指结构域E3泛素蛋白连接酶)在黑色素瘤治疗中的作用与机会
Ji-Fang Zhang,Long-Tian Li,Yue-Ying Yang et al.
Ji-Fang Zhang et al.
Melanoma is an aggressive type of cancer that is prone to developing resistance to targeted therapies and immunotherapies, so it is necessary to seek novel therapeutic opportunities. RING finger E3 ubiquitin ligases (RNFs) play a crucial ro...
Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion [0.03%]
内质网和高尔基体应激信号介导的蛋白质分泌调控
Ketsia Bakambamba,Manon Nivet,Sophie Martin et al.
Ketsia Bakambamba et al.
The eukaryotic secretory pathway (SP) is essential to ensure cellular functions and multicellular communication. The early SP is constituted mostly of the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Go...
Regulation of mitochondrial function during spermatogenesis and sperm maturation [0.03%]
调节生精过程中和精子成熟过程中的线粒体功能
Kai Meng,Ziming Zhu,Haocheng Jia et al.
Kai Meng et al.
With the recent increase in the incidence of male infertility, greater attention is being paid to male reproductive health. The causes of male infertility are complex, and damage occurring during any process from spermatogenesis to fertiliz...
CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion [0.03%]
新型的体外组织模型中的CRISPR和化合物筛选鉴定出DNA损伤反应1和血管紧张素转换酶作为癌症细胞入侵的调节因子
Junnan Liu,Wencheng Jiang,Xue Wang et al.
Junnan Liu et al.
Background: Bladder cancer (BC) can be characterized clinically as either non-muscle-invasive (NMIBC) or muscle-invasive (MIBC). While NMIBC generally has a favorable prognosis, MIBC is characterized by high morbidity and...
DNASE1L3 functions as a significant metastatic suppressor by attenuating MYH9/β-catenin/c-Jun/LncRNA-KDM4A-induced E-cadherin ubiquitination degradation in nasopharyngeal carcinoma [0.03%]
DNA酶1L3通过减弱MYH9/β-catenin/c-Jun/LncRNA-KDM4A诱导的E-钙粘蛋白泛素化降解在鼻咽癌中发挥显著的转移抑制作用
Xingyu Tao,Xiong Liu,Xiangdong Zhao et al.
Xingyu Tao et al.
Background: Deoxyribonuclease 1 Like 3 (DNASE1L3) is a member of the deoxyribonuclease I family that is associated with some diseases, including systemic lupus erythematosus and hypocomplementemic urticarial vasculitis. R...
Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes [0.03%]
血清素作用生理和病理过程中的作用：神经传递之外
Jia-Ming Wang,Feng-Hao Zhang,Yi-Ru Chen et al.
Jia-Ming Wang et al.
Serotonin, also known as 5-HT, is a classical neurotransmitter produced both in the nervous system and in non-nervous system. Its involvement in various fundamental physiological processes and pathogenic conditions is significant, as it bin...