STUB1 downregulates TOP2A through a dual mechanism of ubiquitination and FOXM1-mediated transcription repression, suppressing breast cancer growth and enhancing sensitivity to chemotherapy [0.03%]
STUB1通过泛素化和FOXM1介导的转录抑制双重机制下调TOP2A，抑制乳腺癌生长并增强对化疗的敏感性
Baohui Yue,Qiaoling Xiang,Huimin Qiu et al.
Baohui Yue et al.
Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells [0.03%]
间充质基质细胞体外软骨发生过程中肝素对SMAD2/3的双向调节及抗 hypertrophy 作用
Sven Schmidt,Safak Chasan,Helen F Dietmar et al.
Sven Schmidt et al.
Background: Endochondral instead of chondral differentiation hinders mesenchymal stromal cell (MSC) application for clinical cartilage regeneration. We previously showed that heparin-polyethylene glycol (PEG) hydrogels lo...
Persistent PI3K-AKT signaling fortifies cellular defense against oxidative stress and ferroptosis through augmented mitochondrial fitness [0.03%]
持续的PI3K-AKT信号通过增强线粒体健康来加强细胞对氧化应激和铁死亡的防御
Xin Xie,Shanshan Wang,Wentao Zeng et al.
Xin Xie et al.
Post-translational modifications of selective autophagy receptors: orchestrating cellular homeostasis, disease pathogenesis, and therapeutic opportunities [0.03%]
选择性自噬受体的翻译后修饰：协调细胞稳态、疾病发生及治疗机会
Wenyun Zhu,Xiaohui Wang,Qing Li et al.
Wenyun Zhu et al.
Endothelial Ffar4 protects against diabetic kidney disease by potentiating endogenous retinoic acid metabolism [0.03%]
内皮FFAR4通过增强内源性视黄酸代谢来保护糖尿病肾脏疾病
Jiayu Li,Siyuan Cui,Wei Wang et al.
Jiayu Li et al.
G-quadruplex stabilization via small molecules as a potential anti-cancer strategy [0.03%]
通过小分子稳定G-四链体作为潜在的抗肿瘤策略
Chunshuang Li,Jialian Liu,Ruoxi Wang
Chunshuang Li
mTORC1 as a metabolic rheostat coordinates hormonal signals and cellular proliferation to sustain endometrial competence [0.03%]
mTORC1作为代谢节流阀协调激素信号和细胞增殖以维持子宫内膜能力
Yadong Sun,Shuo Wan,Mingyue Zhao et al.
Yadong Sun et al.
LncRNA MEG3 regulates the development of porcine skeletal muscle satellite cells by enhancing HMGA1 stability [0.03%]
长链非编码RNA MEG3通过提高HMGA1稳定性来调节猪骨骼肌卫星细胞的发育
Quan Liu,Honghong Zhou,Chong Fu et al.
Quan Liu et al.
miR-223-3p improves macrophage polarization balance and mitochondrial metabolism to ameliorate uveitis by orchestrating P65Lys310 acetylation through RBPJ/HDAC1 axis [0.03%]
miR-223-3p通过RBPJ/HDAc1轴调控P65lys310乙酰化以改善脉络膜视网膜炎中巨噬细胞极化平衡和线粒体代谢
Yuan Peng,Bin Liu,Shuqin Xu et al.
Yuan Peng et al.
GPA33 forms a distinct diagnostic target class to Claudin 18.2 in oesophageal adenocarcinoma enabling the development of a novel GPA33 antibody-based detection platform [0.03%]
GPA33在食管腺癌中形成一个独特的诊断目标类，不同于Claudin 18.2，从而能够开发出新型的GPA33抗体检测平台
Jack Brydon,Radovan Krejcir,Filip Zavadil-Kokas et al.
Jack Brydon et al.
Background: Oesophageal adenocarcinoma (OAC) is a cancer of high unmet clinical need. Because of tumour heterogeneity, it is likely that OAC will be stratified into several subtypes. Claudin 18.2 antibodies form emerging ...