Multi-omic screening identifies RBMXL3 as a primate-specific RNA-binding protein and candidate regulator of RNA metabolism in human spermatogenesis [0.03%]
多组学筛选识别出RBMXL3为灵长类特异性RNA结合蛋白和人类精子发生中潜在的RNA代谢调节因子
Agata J Barszcz,Katarzyna Tutak,Joanna Zyprych-Walczak et al.
Agata J Barszcz et al.
Background: RBMXL3 is a primate-specific gene localized on the X chromosome, of which the expression is detectable mainly in the male gonad. So far, very little is known about the RBMXL3 protein function and its molecular...
Enolase 2-mediated lactylation-dependent disruption of the GNL3-MDM2-p53 axis in age-related osteoarthritis [0.03%]
丙二酸乳酰化干扰GNL3-MDM2-p53轴介导年龄相关性骨关节炎的发展
Feng Hua,Jiangyu Nan,Rong Wu et al.
Feng Hua et al.
Background: Age-related osteoarthritis (OA) involves metabolic dysregulation and chondrocyte senescence. This study examined the nonmetabolic role of enolase 2 (ENO2) in OA pathogenesis and its therapeutic potential. ...
HucMSC-mediated stromal metabolic reprogramming in reactivating aged ovaries: a single-cell transcriptomic perspective [0.03%]
人脐带间充质干细胞介导的卵巢微环境代谢重编程激活衰老卵泡的单细胞转录组学研究
Ying-Yi Zhang,Yuqing Mei,Weijie Yang et al.
Ying-Yi Zhang et al.
Background: Aging-induced decline in ovarian function and oocyte quality contributes to female infertility. However, the mechanisms underlying human umbilical cord-derived mesenchymal stem cell (HucMSC)-mediated rejuvenat...
GPR161 contributes to macrophage glycolytic reprogramming via targeting C5aR1 in acute lung injury [0.03%]
GPR161通过靶向C5aR1参与急性肺损伤中巨噬细胞糖酵解重编程
Yu-Huan Li,Xue Yang,Ying Chen et al.
Yu-Huan Li et al.
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are severe respiratory disorders characterized by a dysregulated and excessive inflammatory response within the pulmonary system. Recent studies h...
Neutrophils blend innate and adaptive immunity in early breast milk [0.03%]
中性粒细胞在早期母乳中融合先天性和适应性免疫系统
Gema Gomez-Casado,Natalia Saldaña-García,Antonio Cantarero-Cuenca et al.
Gema Gomez-Casado et al.
Background: Breast milk not only is the most optimal source of nutrition for newborns but also provides crucial immune support. While there is extensive evidence highlighting the health benefits of breastfeeding, the scie...
m6A-modificated Linc00707 promotes the progression of TNBC via U2AF2-mediated alternative splicing of ATG4B [0.03%]
m6A修饰的Linc00707通过U2AF2介导的ATG4B可变剪接促进三阴性乳腺癌的发展
Hongli Li,Yong Li,Qinghua Liu et al.
Hongli Li et al.
Background: Triple-negative breast cancer (TNBC) represents a clinically aggressive breast cancer subtype with limited therapeutic options. Emerging evidence suggests that long intergenic noncoding RNA 00707 (Linc00707) p...
Genomic context of mutations in MIR142 in blood cancers: summary and integrative analysis [0.03%]
MIR142血液肿瘤突变的基因组背景：总结和综合分析
Wladyslaw Wegorek,Adrian Tire,Daniel Kuznicki et al.
Wladyslaw Wegorek et al.
MIR142 is the most frequently mutated microRNA (miRNA) gene in cancer, with recurrent alterations observed particularly in hematologic malignancies of lymphoid origin. It is expressed at very high levels in blood cells and plays an essentia...
Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice [0.03%]
发现一种大麻二酚衍生物的瞬时受体电位香草酸受体4抑制剂以减少小鼠肺水肿和肺血管通透性
Yassir Arfath,Pankaj Singh Cham,Tusharika Kotra et al.
Yassir Arfath et al.
Introduction: Activation of TRPV4 ion channel during acute lung injury (ALI) exacerbates lung dysfunction by promoting edema and inflammation. Pharmacological inhibition of TRPV4 signaling in the lungs offers protective b...
QSOX1 confers ferroptosis resistance via redox modification of SLC7A11 in colorectal cancer [0.03%]
结直肠癌中铁沉积通过硫氧还蛋白对SLC7A11的氧化修饰调控铁死亡抵抗作用
Mengqi Jia,Hanxiang Chen,Yulin Liu et al.
Mengqi Jia et al.
Background: Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target for colorectal cancer (CRC). However, the precise mechanisms by which CRC...
H2S induces apoptosis of tumors with high IDO1 expression via NR4A1-BCL-2 and SOCS3 pathways [0.03%]
硫化氢通过NR4A1-BCL2和SOCS3途径诱导高IDO1表达肿瘤的凋亡
Zhen Ning Tony He,Fangzhou Meng,Xiaoyang Qian et al.
Zhen Ning Tony He et al.
Background: Hydrogen sulfide (H2S) has been reported to exert both protumor and antitumor functions. It is worthy to clarify the condition under which H2S exerts antitumor effects and its underlying mechanism. Our previou...