Heterogeneity of macrophages in PD-1/PD-L1 inhibitor therapy: a single-cell perspective [0.03%]
PD-1/PD-L1抑制剂治疗中的巨噬细胞异质性：单细胞视角
Jinjing Wu,Dan Zhou,Kunpeng Jiang et al.
Jinjing Wu et al.
Therapeutic blockade of the PD-1/PD-L1 signaling pathway is the focus of tumor immunotherapy. However, drug resistance and irAEs induced by PD-1/PD-L1 inhibitors have emerged as major limitations affecting survival outcomes in patients with...
ZNF662 inhibits oncogenesis through NUPR1/p53 signaling pathway in epithelial ovarian cancer and is regulated by hsa-miR-429 [0.03%]
锌指蛋白662通过NUPR1/p53信号通路抑制上皮性卵巢癌的发生并受hsa-miR-429调控
Zhen Huang,Hongxue Fu,Ling Li et al.
Zhen Huang et al.
Background: Epithelial ovarian cancer (EOC) represents the most lethal malignancy of the female reproductive system, though its etiology and pathogenesis remain incompletely characterized. The Krüppel-associated box doma...
Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons [0.03%]
磷酸蛋白质组分析揭示了亨廷顿舞蹈病患者神经元中的翻译后调节紊乱
Lea Danics,Chandramouli Muralidharan,Ágnes Varga et al.
Lea Danics et al.
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin gene. Although transcriptomic and proteomic changes have been characterized in patient-derived neurons, the contribution of p...
Deorphanisation and functional characterisation of OATP5A1 as transport protein for amino acids and vitamins [0.03%]
OATP5A1的去孤儿化及作为氨基酸和维生素转运蛋白的功能表征
Elena Kohlmann,Nikola K Schmid,Arne Gessner et al.
Elena Kohlmann et al.
Background: Transport proteins are important for the uptake, distribution and elimination of endogenous substances and drugs, and therefore essential for, e.g., cellular metabolism or drug effects. While the export of sub...
Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis [0.03%]
乳酸活化的星形胶质细胞通过外泌体介导的miR-8085/TRIM67/ELK1信号轴促进非小细胞肺癌脑转移
Haiqin Peng,Guilong Tanzhu,Wen Shi et al.
Haiqin Peng et al.
Brain metastasis represents an advanced complication in non-small cell lung cancer (NSCLC), characterized by therapeutic resistance and dismal survival outcomes. Although astrocytes are known to influence tumor progression within the brain ...
Exendin-4 averts all-trans-retinal-driven damage to photoreceptors and the retina via the GLP-1R/PKA/CREB1 signaling axis [0.03%]
exendin-4通过GLP-1R/PKA/CREB1信号轴抵御全反式视黄醛驱动的光感受器和视网膜损伤
Beiting He,Yuling Chen,Peixin Cai et al.
Beiting He et al.
Background: Atrophic macular degeneration comprises dry age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1). These disorders lead to irreversible blindness and still lack effective the...
OTULIN protects hyperoxia-induced neonatal lung injury and modulates mitochondrial protein OPA1 in association with the E3 ubiquitin ligase RNF31 [0.03%]
OTULIN通过与E3泛素连接酶RNF31相互作用来调节线粒体蛋白OPA1从而保护新生鼠肺氧中毒损伤
Li Huang,Qing Liu,Aimin Zhang et al.
Li Huang et al.
The deubiquitinating enzyme OTULIN has been implicated in the development of lung injury, and regulating its expression may either exacerbate or alleviate pulmonary inflammatory damage. In this study, we aimed to investigate the role of deu...
KAP1 SUMOylates and stabilizes SR-A to facilitate glycated LDL transcytosis and accelerate atherosclerosis [0.03%]
KAP1促进糖化LDL跨细胞转运和动脉粥样硬化进展的新机制
Meng Shu,Wenzhuo Cheng,Fangyang Yu et al.
Meng Shu et al.
Background: Atherosclerosis (AS)-associated cardiovascular disease is the main cause of global mortality. The excessive retention of glycated low-density lipoprotein (G-LDL) under the vascular endothelium promotes AS. In ...
AARS1 promotes diabetic kidney disease through rewiring Akt and NF-κB signaling to suppress autophagy and sustain inflammation [0.03%]
AARS1通过重新连接Akt和NF-κB信号传导来抑制自噬并维持炎症从而促进糖尿病肾脏疾病
Lei Tian,Yumeng Wang,Chen Guan et al.
Lei Tian et al.
Background: Diabetic kidney disease (DKD) is characterized by metabolic reprogramming, autophagy impairment, and chronic inflammation, but the molecular mechanisms linking these processes are not fully understood. Lactyla...
KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC [0.03%]
KRASG12V/A146T突变通过增强DNA双链断裂修复与nCRT耐药相关，并支持LARC的深度学习预测框架
Hengchang Liu,Dechao Bu,Guanhua Yu et al.
Hengchang Liu et al.
Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC), yet clinically validated biomarkers for predicting response remain lacking. This study aimed to identif...