Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies [0.03%]
靶向癌细胞突变型p53：从机制研究到治疗策略
H Helena Wu,Sarah Leng,David D Eisenstat et al.
H Helena Wu et al.
Li Gong,Xinyu Lu,Na Ma et al.
Li Gong et al.
CDH4/UBA1/RBMX axis promotes polycystic ovary syndrome progression through YAP1 activation [0.03%]
CDH4/UBA1/RBMX轴通过激活YAP1促进多囊卵巢综合征的发展
Ning Xu,Bo Yu,Yingying Li et al.
Ning Xu et al.
Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K-Akt pathway [0.03%]
20-羟基蜕皮酮治疗肺动脉高压的潜在作用及Mas受体和PI3K-Akt通路的介导作用研究
Tong Lu,Weiwei Jia,Yuefei Wang et al.
Tong Lu et al.
Background: 20-Hydroxyecdysone (20E), a natural polyhydroxylated steroid found in various edible plants, exhibits diverse pharmacological effects. Pulmonary arterial hypertension (PAH) remains challenging to treat owing t...
Macrophage-derived legumain ameliorates excessive mechanical stress-induced ferroptosis of nucleus pulposus cells and intervertebral disc degeneration via integrin αvβ3-Hippo signaling [0.03%]
巨噬细胞来源的半乳糖苷酶通过整合素αvβ3-Hippo信号通路改善椎间盘细胞铁死亡和椎间盘退变中的过度机械应力损伤
Peiyang Wang,Zhiyang Xie,Liting Deng et al.
Peiyang Wang et al.
Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice [0.03%]
ASH2L缺陷通过损害脂肪组织产热促进肥胖发展
Yajie Hu,Jialin Zhao,Chenxi Xiao et al.
Yajie Hu et al.
Background: Epigenetic regulation plays a pivotal role in adipocyte development and thermogenesis. Ash2l, a key component of the COMPASS (Complex of Proteins Associated with Set1) histone methyltransferase, regulates gene...
Targeting dormant cancer cells: ferroptosis as a precision therapeutic strategy [0.03%]
针对休眠的癌细胞：铁死亡作为精准治疗策略
Sijia Hao,Yulu Guo,Qiaozhen Huang et al.
Sijia Hao et al.
Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye [0.03%]
间歇性禁食通过调节CD36及其棕榈酰化来抑制铁死亡从而缓解糖尿病干眼症
Wenhui Wang,Jianwen Xue,Bing Xiao et al.
Wenhui Wang et al.
Combination of Tripterygium glycosides and Lactobacillus paracasei sensitises epithelial ovarian cancer to cisplatin via downregulating Keap1-Nrf2-GPX4 signalling pathway [0.03%]
雷公藤内酯醇联合副干酪乳杆菌通过下调Keap1-Nrf2-GPX4信号通路提高卵巢癌细胞对顺铂敏感性
Meiyun Tian,Xiangdi Zeng,Yanying Zhong et al.
Meiyun Tian et al.
Background: Epithelial ovarian cancer (EOC) is a highly heterogeneous malignancy with significant morbidity and mortality, and cisplatin (DDP) resistance remains a major obstacle in its treatment. Previous studies suggest...
NFAT1+ microglia promote antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1 axis to improve ischemic stroke outcomes [0.03%]
NFAT1+小胶质细胞通过HAS3-HA-LYVE1轴促进抗炎极化和血管生成以改善缺血性卒中预后
Yaochuan Zhang,Xu Cao,Yifu Song et al.
Yaochuan Zhang et al.
Background: Neuroinflammation and angiogenesis are central to post-stroke repair. However, the cellular and molecular mechanisms regulating these events remain incompletely understood. The nuclear factor of activated T ce...