Yong-Yu Gao,Hai-Yang Li,Si-Yu Yang et al.
Yong-Yu Gao et al.
Swine leukocyte antigen class I (SLA-I) molecules are swine orthologs of human MHC class I molecules and are encoded by three classical loci, SLA-1, SLA-2, and SLA-3. By engaging T-cell receptors (TCRs), these cell-surface proteins present ...
Targeting SLK protects against cerebral ischemia-reperfusion injury by regulating USP8-mediated HIF-1α stabilization and RhoA/ROCK activation [0.03%]
靶向SLK通过调节USP8介导的HIF-1α稳定和RhoA/ROCK活化来抵抗脑缺血再灌注损伤
Yuetao Wen,Zhiyu Xiong,Zhiyuan Wang et al.
Yuetao Wen et al.
Introduction: Acute ischemic stroke (AIS) represents a major global contributor to mortality and chronic disability, with few effective therapeutic targets available. Identifying druggable genes associated with AIS is the...
Correction: Targeting fibroblast activation protein-α to treat renal fibrosis [0.03%]
关于靶向纤维活化蛋白-α治疗肾纤维化的更正通知
Li Gong,Xinyu Lu,Na Ma et al.
Li Gong et al.
Published Erratum
Cellular & molecular biology letters. 2026 Jun 30;31(1):103. DOI:10.1186/s11658-026-00967-z 2026
Hepatocellular carcinoma metastasis-immune microenvironment crosstalk: emerging mechanisms and immunotherapy [0.03%]
肝细胞癌转移-免疫微环境互作：新兴机制及免疫治疗
Wenlong Zhu,Yanjie Zhang,Runze Jiang et al.
Wenlong Zhu et al.
Hepatocellular carcinoma (HCC), the most prevalent type of liver cancer globally, imposes a heavy burden on global public health owing to its consistently high incidence and mortality rates. Owing to the characteristics of its tissue struct...
HIF-1α enhances ferroptosis resistance in anaplastic thyroid carcinoma by suppressing ACSL4-mediated lipid metabolic homeostasis [0.03%]
低氧诱导因子-1α通过抑制ACSL4介导的脂质代谢稳态增强甲状腺癌铁死亡抵抗性
Renjie Xie,Ruixue Geng,Yuchen Wang et al.
Renjie Xie et al.
Background: Anaplastic thyroid carcinoma (ATC) exhibits extreme malignancy with a median survival of less than 6 months. Traditional therapeutic approaches yield limited efficacy, necessitating the urgent identification o...
Sperm surface protein disulfide isomerase ERp57 is crucial for mammalian fertilization but functions independently of IZUMO1 [0.03%]
精子表面蛋白二硫键异构酶ERp57对于哺乳动物受精至关重要，但其功能与IZUMO1无关
Emily Forster,Sophie Dupuis,Côme Ialy-Radio et al.
Emily Forster et al.
Background: Human fertilization requires fusion of spermatozoon and oocyte membranes to form a diploid zygote, beginning with adhesion mediated by spermatozoon IZUMO1 and oocyte JUNO. Current models propose that IZUMO1 di...
Cannabidiol alleviates traumatic brain injury-induced neuronal damage and cognitive deficits by inhibiting ferroptosis via the TRPV1/MCU/PI3K/Akt pathway [0.03%]
大麻二酚通过TRPV1/MCU/PI3K/Akt信号通路抑制铁死亡从而缓解创伤性脑损伤所致的神经元损害和认知障碍
Yejia Xu,Xiong Li,Zhiya Gu et al.
Yejia Xu et al.
Background: Traumatic brain injury (TBI) is a common surgical traumatic condition that poses a significant threat to human health and working capacity. However, effective treatments to improve its prognosis remain limited...
Mitigating nucleus pulposus cell senescence in intervertebral disk degeneration: the role of nodakenin in SIRT6 and PINK1/Parkin-associated mitophagy signaling [0.03%]
椎间盘退变中髓核细胞衰老的缓解：nodakenin在SIRT6和PINK1/Parkin相关线粒体自噬信号通路中的作用
Daqian Zhou,Liquan Wang,Yang Zhou et al.
Daqian Zhou et al.
Intervertebral disc degeneration (IVDD) is a common and challenging chronic condition in orthopedics, primarily characterized by the aging of nucleus pulposus cells (NPC). Current treatment strategies for IVDD, particularly those targeting ...
piR-26681 suppresses ovarian cancer progression by enhancing METTL3/METTL14-mediated m6A modification of FBXO16 and impairing DNA repair via MORF4L1 degradation [0.03%]
piR-26681通过增强METTL3/METTL14介导的FBXO16的m6A修饰并降解MORF4L1来抑制DNA修复及卵巢癌进展
Jie-Lin Wang,Qing-Hua Wu,Jing Yuan et al.
Jie-Lin Wang et al.
Background: Survival rates for ovarian cancer drop sharply at late-stages due to late diagnosis. Although PARP inhibitors are effective in homologous recombination-deficient (HRD) tumors, their efficacy in homologous reco...
Human primordial germ cell heterogeneity in vitro is associated with distinctive biological states [0.03%]
人类原始生殖细胞异质性与独特的生物学状态有关
Young Sun Hwang,Qiu Ya Wu,Sissy E Wamaitha et al.
Young Sun Hwang et al.
Background: Primordial germ cells (PGCs) exhibit molecular heterogeneity during development, yet whether this reflects functionally distinct states remains unclear. ...