Cerivastatin represses atherogenic gene expression through the induction of KLF2 via isoprenoid metabolic pathways [0.03%]
他汀类药物抑制动脉粥样硬化基因表达的机制研究
Jiyuan Zhao,Selvamuthu K Natarajan,Nicolas Chronos et al.
Jiyuan Zhao et al.
Earlier clinical studies have reported that cerivastatin has an anti-atherosclerotic effect that is unique among the statins. In our study, human THP-1 macrophage cells were used to study the effects of various statins on the expressions of...
Shuang-Yang Tang,Yan-Ping Wan,Yi-Mou Wu
Shuang-Yang Tang
Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell surv...
Homology arms of targeting vectors for gene insertions and CRISPR/Cas9 technology: size does not matter; quality control of targeted clones does [0.03%]
基因插入靶向载体的同源臂及CRISPR/Cas9技术：长度无关紧要；目标克隆的质量控制很重要
Silvia Petrezselyova,Slavomir Kinsky,Dominika Truban et al.
Silvia Petrezselyova et al.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) technology has brought rapid progress in mammalian genome editing (adding, disrupting or changing the sequence of specific sites) by increasing th...
In silico screening of alleged miRNAs associated with cell competition: an emerging cellular event in cancer [0.03%]
假miRNA的计算筛选及其与细胞竞争的关系：癌变过程中一种新兴的细胞事件
Manish Patel,Bhavesh Antala,Neeta Shrivastava
Manish Patel
Cell competition is identified as a crucial phenomenon for cancer and organ development. There is a possibility that microRNAs (miRNAs) may play an important role in the regulation of expression of genes involved in cell competition. In sil...
1H NMR-based metabolic profiling for evaluating poppy seed rancidity and brewing [0.03%]
基于超极化氢核磁共振代谢轮廓表征鸦片籽酸败及浸提过程
Ewa Jawień,Adam Ząbek,Stanisław Deja et al.
Ewa Jawień et al.
Poppy seeds are widely used in household and commercial confectionery. The aim of this study was to demonstrate the application of metabolic profiling for industrial monitoring of the molecular changes which occur during minced poppy seed r...
Somatic stem cell aging and malignant transformation--impact on therapeutic application [0.03%]
体细胞干细胞衰老及恶性转化的治疗学意义
Marcela Kuniakova,Lenka Oravcova,Zuzana Varchulova-Novakova et al.
Marcela Kuniakova et al.
Somatic stem cells possess unique properties of self-renewal and plasticity which make them promising candidates for use in tissue engineering and regenerative medicine, in addition to serving as efficient delivery vehicles in site-specific...
Coexistence of rare variant HbD Punjab [α2β2(121(Glu→Gln))] and alpha 3.7 kb deletion in a young boy of Hindu family in West Bengal, India [0.03%]
印度西孟加拉邦一个印度教家庭的年轻男孩罕见变异HbD Punjab[α2β2(121(Glu→Gln))]和alpha 3.7 kb缺失共存病例报告
Arijit Ghosh,Jayasri Basak,Ashis Mukhopadhyay
Arijit Ghosh
HbD Punjab is a variant of hemoglobin which occurs as a result of mutation in codon 121 (GAA>CAA) of the β-globin gene, which replaces glutamic acid with glutamine (Glu→Gln). The heterozygous state of HbD does not produce any clinical or ...
Dariusz Kikut-Ligaj,Joanna Trzcielińska-Lorych
Dariusz Kikut-Ligaj
The sensitivity of taste in mammals varies due to quantitative and qualitative differences in the structure of the taste perception organs. Gustatory perception is made possible by the peripheral chemosensory organs, i.e., the taste buds, w...
Non-cooperative immobilization of residual water bound in lyophilized photosynthetic lamellae [0.03%]
光合lamellae冷冻干燥后残留结合水的非合作型固定化
Hubert Harańczyk,Ewelina Baran,Piotr Nowak et al.
Hubert Harańczyk et al.
This study applied 1H-NMR in time and in frequency domain measurements to monitor the changes that occur in bound water dynamics at decreased temperature and with increased hydration level in lyophilizates of native wheat photosynthetic lam...
Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis [0.03%]
亚洲印度人的超氧化物歧化酶2多态性和骨质疏松症的基因关联分析
Chaitali Botre,Arjun Shahu,Neeraj Adkar et al.
Chaitali Botre et al.
Oxidative stress plays an important role in the development of osteoporosis. The present cross-sectional study focuses on mapping single nucleotide polymorphisms (SNPs) in the mitochondrial manganese superoxide dismutase (SOD2) gene in Asia...