Elevated Pressure Enhanced Trail-Induced Apoptosis in Hepatocellular Carcinoma Cells Via Erk1/2-Inactivation [0.03%]
压力增大通过 erk1/2 失活增强肝癌细胞凋亡
Eunyoung Hong,Eunil Lee,Joonhee Kim et al.
Eunyoung Hong et al.
The high frequency of intrinsic resistance to TNF-related apoptosisinducing ligand (TRAIL) in tumor cell lines has necessitated the development of strategies to sensitize tumors to TRAIL-induced apoptosis. We previously showed that elevated...
The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine [0.03%]
生物活性鞘脂S1P和C1P对多能基质细胞的影响——再生医学的新机遇
Krzysztof Marycz,Agnieszka Śmieszek,Marta Jeleń et al.
Krzysztof Marycz et al.
Sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) belong to a family of bioactive sphingolipids that act as important extracellular signaling molecules and chemoattractants. This study investigated the influence of S1P and C1P on...
FunPred-1: protein function prediction from a protein interaction network using neighborhood analysis [0.03%]
利用邻域分析从蛋白质相互作用网络预测蛋白质功能的FunPred-1方法
Sovan Saha,Piyali Chatterjee,Subhadip Basu et al.
Sovan Saha et al.
Proteins are responsible for all biological activities in living organisms. Thanks to genome sequencing projects, large amounts of DNA and protein sequence data are now available, but the biological functions of many proteins are still not ...
Patricia Sanz-Ramos,Javier Dotor,Iñigo Izal-Azcárate
Patricia Sanz-Ramos
We aim to demonstrate the role of Alk receptors in the response of hydrogel expansion. Chondrocytes from rat knees were cultured onto plastic and hydrogel surfaces. Alk-1 and Alk-5 were overexpressed or silenced and the effects on cells dur...
Rapid proliferation of activated lymph node CD4(+) T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression [0.03%]
活化淋巴结CD4+T细胞的快速增值是通过大大缩短细胞周期分裂间期实现的
Takuya Mishima,Shoko Toda,Yoshiaki Ando et al.
Takuya Mishima et al.
Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the first two cell cycle times of ...
Mary Poupot,Frédéric Boissard,Delphine Betous et al.
Mary Poupot et al.
Phosphoantigens (PAgs) activate Vγ9Vδ2 T lymphocytes, inducing their potent and rapid response in vitro and in vivo. However, humans and nonhuman primates that receive repeated injections of PAgs progressively lose their Vγ9Vδ2 T cell r...
The effect of buffalo CD14 shRNA on the gene expression of TLR4 signal pathway in buffalo monocyte/macrophages [0.03%]
水牛CD14干扰对水牛单核/巨噬细胞TLR4信号通路基因表达的影响
Xiangping Li,Meiqing Li,Shihai Huang et al.
Xiangping Li et al.
CD14 plays a crucial role in the inflammatory response to lipopolysaccharide (LPS), which interacts with TLR4 and MD-2 to enable cell activation, resulting in inflammation. Upstream inhibition of the inflammation pathway mediated by bacteri...
Jing Yang,Nan Su,Xiaolan Du et al.
Jing Yang et al.
Bone displays suppressed osteogenesis in inflammatory diseases such as sepsis and rheumatoid arthritis. However, the underlying mechanisms have not yet been clearly explained. To identify the gene expression patterns in the bone, we perform...
Promoted megakaryocytic differentiation of K562 cells through oxidative stress caused by near ultraviolet irradiation [0.03%]
由近紫外辐射诱导的氧化应激促进K562细胞巨核细胞分化
Retno Wahyu Nurhayati,Yoshihiro Ojima,Naoki Nomura et al.
Retno Wahyu Nurhayati et al.
Reactive oxygen species (ROS) have been proven to be important activators for various cellular activities, including cell differentiation. Several reports showed the necessity of ROS during cell differentiation of the megakaryocytic (MK) li...
Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture [0.03%]
ANO1是一个更好的标记物用于卡哈尔细胞间质细胞培养转录分析而不是C-Kit
Raúl Loera-Valencia,Xuan-Yu Wang,George W J Wright et al.
Raúl Loera-Valencia et al.
The interstitial cells of Cajal (ICC) drive the slow wave-associated contractions in the small intestine. A commonly used marker for these cells is c-Kit, but another marker named Ano1 was recently described. This study uses single-cell RT-...