Chronic pantoprazole exposure induces behavioral deficits and region‑specific molecular changes in the rat motor cortex and cerebellum [0.03%]
长期潘托拉唑暴露诱导大鼠运动皮层和小脑的行为缺陷和区域特异性分子变化
Emine Caglar,Birsen Elibol,Nurhayat Polat et al.
Emine Caglar et al.
Proton pump inhibitors are widely used, but their long‑term effects on the central nervous system are not well understood. In this study, we investigated whether chronic pantoprazole use alters sensorimotor function, oxidative stress, infl...
Modulation of electrically evoked hippocampal epileptiform activity by exogenous orexins in the rat CA1 field [0.03%]
外源性食欲素对大鼠海马CA1区电诱发癫癎样活动的调制作用
Tsira Kapanadze,Mariam Kurasbediani,Gia Kutelia et al.
Tsira Kapanadze et al.
In vivo electrophysiological experiments were conducted to evaluate the effects of intraventricular and cortical administration of orexins on electrically evoked epileptiform discharges (EEDs) in the hippocampal CA1 field. Bipolar electrode...
The effect of clozapine and GABAA receptor drugs on scopolamine‑induced amnesia in male mice [0.03%]
氯氮平和GABAA受体药物对雄性小鼠东莨菪碱诱导的学习记忆障碍的影响
Fatemeh Khakpai,Mohaddeseh Ebrahimi-Ghiri,Sakineh Alijanpour et al.
Fatemeh Khakpai et al.
Scopolamine, a muscarinic acetylcholine receptor antagonist, disturbs learning and memory processes. Clozapine, an atypical antipsychotic, has beneficial predictive validity for confirming principles to help new treatment approaches. It cou...
LRRK2 mutations: at the crossroads of dopamine, iron, and calcium imbalance in Parkinson's disease [0.03%]
LRRK2突变：在帕金森病中多巴胺、铁和钙平衡失调的交汇点
Weronika Skarżyńska,Aleksandra Moskal,Jacek Kuźnicki
Weronika Skarżyńska
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. The G2019S mutation in the leucine‑rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of familial and s...
Effects of transcranial direct current stimulation in multiple sclerosis: Recent findings of clinical studies and animal models [0.03%]
经颅直流电刺激在多发性硬化中的作用：近期临床研究和动物模型的发现
Maedeh Hashemi,Mohammad Hassan Tajik,Parinaz Javanbakht et al.
Maedeh Hashemi et al.
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) affecting millions worldwide, leading to significant disability. Current treatments focus on symptom management and reducing disease exacerbation...
Microglia up‑regulate thromboxane A2 synthesis genes in response to C6 glioma‑conditioned medium [0.03%]
小胶质细胞通过上调血栓素A2合成基因响应C6胶质瘤条件培养基反应
Michał Dąbrowski,Beata Kaza,Bartłomiej Gielniewski et al.
Michał Dąbrowski et al.
Microglia accumulate in malignant gliomas and play a pivotal role in tumor progression. Using single‑cell RNA sequencing studies researchers have probed gene expression in the myeloid cells in experimental gliomas at relatively late stages...
Pharmacological modulation of anxiety‑like and depression‑like behaviors in nerve‑ligated mice: regarding the effects of citicoline and bupropion [0.03%]
胞磷胆碱和安非他酮对坐骨神经结扎小鼠焦虑样和抑郁样行为的药理学调节作用研究
Bardia Hajikarimloo,Negar Raissi-Dehkordi,Nastaran Raissi-Dehkordi et al.
Bardia Hajikarimloo et al.
Neuropathic pain is a condition that results from nerve injury. There is a relationship between neuropathic pain and mood disorders. Citicoline, when used as a dietary supplement, exhibits neuroprotective, antidepressant, and anxiolytic pro...
Projections from thalamic nucleus reuniens to medial septum enable extinction of remote fear memory [0.03%]
背侧丘脑联合核到腹内侧海马区的投射促进远期恐惧记忆的消退
Kamil F Tomaszewski,Olga Gajewska-Woźniak,Magdalena Ziółkowska et al.
Kamil F Tomaszewski et al.
Aversive experiences lead to the formation of long‑lasting memories. Despite the need to better understand how enduring fear memories can be attenuated, the underlying brain circuits remain largely unknown. In this study, employing a combi...
Chronic pinacidil attenuates the pentylenetetrazole‑induced kindling in rats [0.03%]
慢性平阳霉素减轻戊四唑诱导的大鼠类痫发作
Artur Teixeira Pereira,Erica Aparecida Gelfuso,Luiz Luciano Falconi-Sobrinho et al.
Artur Teixeira Pereira et al.
Seizures in epilepsy result from excessive neuronal electrical discharges. Imbalances in potassium homeostasis can increase neuronal excitability and trigger epileptic seizures. Drugs that enhance potassium currents are expected to suppress...
Effects of adrenergic receptor modulators on nuclear LCC‑channels in Purkinje neurons [0.03%]
肾上腺素受体调节剂对浦肯野神经元核LCC通道的影响
Olena Kotyk,Serhii Nadtoka,Tetiana Vynohradova et al.
Olena Kotyk et al.
Large conductance cation channels (LCC‑channels), located in the nuclear membrane, are potential mediators of potassium (K+) countercurrent during calcium ion (Ca2+) release from intracellular stores. This study examined the effects of epi...