Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications [0.03%]
来源于脂肪及其他组织的间充质干细胞的基本生物学性质及其临床应用
Hakan Orbay,Morikuni Tobita,Hiroshi Mizuno
Hakan Orbay
Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue d...
Stem cells in large animal models of retinal and neurological disease [0.03%]
干细胞在视网膜和神经疾病大型动物模型中的应用
Henry Klassen,Budd A Tucker,Chee G Liew et al.
Henry Klassen et al.
James D Hoerter,Patrick Bradley,Alexandria Casillas et al.
James D Hoerter et al.
Recent studies suggest that extrafollicular dermal melanocyte stem cells (MSCs) persist after birth in the superficial nerve sheath of peripheral nerves and give rise to migratory melanocyte precursors when replacements for epidermal melano...
The promise of human induced pluripotent stem cells in dental research [0.03%]
诱导多能干细胞在牙髓再生研究中的应用前景展望
Thekkeparambil Chandrabose Srijaya,Padmaja Jayaprasad Pradeep,Rosnah Binti Zain et al.
Thekkeparambil Chandrabose Srijaya et al.
Induced pluripotent stem cell-based therapy for treating genetic disorders has become an interesting field of research in recent years. However, there is a paucity of information regarding the applicability of induced pluripotent stem cells...
Drug discovery models and toxicity testing using embryonic and induced pluripotent stem-cell-derived cardiac and neuronal cells [0.03%]
基于胚胎和诱导多能干细胞的药物发现模型及心脏和神经细胞毒性检测
Rahul S Deshmukh,Krisztián A Kovács,András Dinnyés
Rahul S Deshmukh
Development of induced pluripotent stem cells (iPSCs) using forced expression of specific sets of transcription factors has changed the field of stem cell research extensively. Two important limitations for research application of embryonic...
Ex vivo expansion of human mesenchymal stem cells in defined serum-free media [0.03%]
不含血清的培养基体外扩增人骨髓间充质干细胞
Sunghoon Jung,Krishna M Panchalingam,Lawrence Rosenberg et al.
Sunghoon Jung et al.
Human mesenchymal stem cells (hMSCs) are presently being evaluated for their therapeutic potential in clinical studies to treat various diseases, disorders, and injuries. To date, early-phase studies have indicated that the use of both auto...
Patricia L Martínez-Morales,Isabel Liste
Patricia L Martínez-Morales
Progress in understanding neurodegenerative cell biology in Parkinson's disease (PD) has been hampered by a lack of predictive and relevant cellular models. In addition, the lack of an adequate in vitro human neuron cell-based model has bee...
Stimulation of cultured h9 human embryonic stem cells with thyroid stimulating hormone does not lead to formation of thyroid-like cells [0.03%]
人胚胎干细胞(H9)系不能被甲状腺刺激激素诱导分化成为甲状腺细胞类型
Mykola I Onyshchenko,Igor G Panyutin,Irina V Panyutin et al.
Mykola I Onyshchenko et al.
The sodium-iodine symporter (NIS) is expressed on the cell membrane of many thyroid cancer cells, and is responsible for the radioactive iodine accumulation. However, treatment of anaplastic thyroid cancer is ineffective due to the low expr...
Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts [0.03%]
c-Myc蛋白的重编程时间要求——将小鼠成纤维细胞重新编程的小鼠实验研究
Corey Heffernan,Huseyin Sumer,Luis F Malaver-Ortega et al.
Corey Heffernan et al.
Exogenous expression of Oct4, Sox2, Klf4, and cMyc forces mammalian somatic cells to adopt molecular and phenotypic characteristics of embryonic stem cells, commencing with the required suppression of lineage-associated genes (e.g., Thy1 in...
Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A [0.03%]
人肌前体细胞通过半乳糖凝集素和Semaphorin-3A发挥免疫抑制作用
Séverine Lecourt,Yves Lepelletier,Valérie Vanneaux et al.
Séverine Lecourt et al.
In human skeletal muscle, myoblasts represent the main population of myogenic progenitors. We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineage...