Growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration [0.03%]
生长因子和抗分解物质在椎间盘退变的预防和治疗中的作用
Umile Giuseppe Longo,Stefano Petrillo,Edoardo Franceschetti et al.
Umile Giuseppe Longo et al.
Intervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment...
Umile Giuseppe Longo,Mattia Loppini,Francisco Forriol et al.
Umile Giuseppe Longo et al.
Meniscal tears are the most common knee injuries and have a poor ability of healing. In the last few decades, several techniques have been increasingly used to optimize meniscal healing. Current research efforts of tissue engineering try to...
Tissue engineering for rotator cuff repair: an evidence-based systematic review [0.03%]
基于证据的肩袖修复组织工程系统回顾
Nicola Maffulli,Umile Giuseppe Longo,Mattia Loppini et al.
Nicola Maffulli et al.
The purpose of this systematic review was to address the treatment of rotator cuff tears by applying tissue engineering approaches to improve tendon healing, specifically platelet rich plasma (PRP) augmentation, stem cells, and scaffolds. O...
S MacLean,W S Khan,A A Malik et al.
S MacLean et al.
The use of stems cells in tendon repair is of particular interest given the frequency of tendon injuries worldwide together with the technical difficulty often encountered when repairing or augmenting tendons. Stems cells have the capabilit...
An osteoconductive, osteoinductive, and osteogenic tissue-engineered product for trauma and orthopaedic surgery: how far are we? [0.03%]
具有骨传导性、骨诱导性和骨生成性的组织工程产品在创伤和骨科手术中的应用：我们还有多远？
Wasim S Khan,Faizal Rayan,Baljinder S Dhinsa et al.
Wasim S Khan et al.
The management of large bone defects due to trauma, degenerative disease, congenital deformities, and tumor resection remains a complex issue for the orthopaedic reconstructive surgeons. The requirement is for an ideal bone replacement whic...
Umile Giuseppe Longo,Mattia Loppini,Alessandra Berton et al.
Umile Giuseppe Longo et al.
Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including...
Multipotent mesenchymal stromal stem cell expansion by plating whole bone marrow at a low cellular density: a more advantageous method for clinical use [0.03%]
通过低细胞密度的完整骨髓培养板层来扩增多能间充质基质干细胞：临床应用更佳的方法
Katia Mareschi,Deborah Rustichelli,Roberto Calabrese et al.
Katia Mareschi et al.
Mesenchymal stem cells (MSCs) are a promising source for cell therapy due to their pluripotency and immunomodulant proprieties. As the identification of "optimal" conditions is important to identify a standard procedure for clinical use. Pe...
Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry [0.03%]
非洲爪蟾胚胎神经衍生组织中存在一致的生物电左/右不对称性
Vaibhav P Pai,Laura N Vandenberg,Douglas Blackiston et al.
Vaibhav P Pai et al.
Consistent left-right asymmetry in organ morphogenesis is a fascinating aspect of bilaterian development. Although embryonic patterning of asymmetric viscera, heart, and brain is beginning to be understood, less is known about possible subt...
Mirella Dottori,Mary Familari,Stefan Hansson et al.
Mirella Dottori et al.
Jan Kramer,Francesco Dazzi,Massimo Dominici et al.
Jan Kramer et al.