Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential [0.03%]
基于激光的人类iPS和ES细胞的传播产生可重复培养物并增强分化潜能
Kristi A Hohenstein Elliott,Cory Peterson,Anuradha Soundararajan et al.
Kristi A Hohenstein Elliott et al.
Proper maintenance of stem cells is essential for successful utilization of ESCs/iPSCs as tools in developmental and drug discovery studies and in regenerative medicine. Standardization is critical for all future applications of stem cells ...
Mesenchymal stromal cells do not increase the risk of viral reactivation nor the severity of viral events in recipients of allogeneic stem cell transplantation [0.03%]
间充质基质细胞不会增加异基因干细胞移植受者的病毒再活化风险或病毒事件的严重程度
Giovanna Lucchini,Erica Dander,Fabio Pavan et al.
Giovanna Lucchini et al.
Mesenchymal stromal cells (MSC) are tested in clinical trials to treat graft versus host disease (GvHD) after stem cell transplantation (SCT). In vitro studies demonstrated MSC's broad immunosuppressive activity. As infections represent a m...
Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming [0.03%]
VSV-G介导的间充质干细胞与心肌细胞融合促进干细胞重编程
Nicholas A Kouris,Jeremy A Schaefer,Masato Hatta et al.
Nicholas A Kouris et al.
Mesenchymal stem cells (MSCs) spontaneously fuse with somatic cells in vivo, albeit rarely, and the fusion products are capable of tissue-specific function (mature trait) or proliferation (immature trait), depending on the microenvironment....
Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells [0.03%]
玻璃体内注射糖皮质激素对间充质干细胞的影响
Raffaele Nuzzi,Monica Gunetti,Deborah Rustichelli et al.
Raffaele Nuzzi et al.
Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several trea...
Marc Thier,Bernhard Münst,Stephanie Mielke et al.
Marc Thier et al.
Induced pluripotent stem (iPS) cells represent an attractive option for the derivation of patient-specific pluripotent cells for cell replacement therapies as well as disease modeling. To become clinically meaningful, safe iPS cells need to...
Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering [0.03%]
细胞重编程、诱导多能干细胞的局限性及在牙科学中的克服策略
Gaskon Ibarretxe,Antonia Alvarez,Maria-Luz Cañavate et al.
Gaskon Ibarretxe et al.
The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on deman...
Youwei Wang,Zhi-Bo Han,Yong-Ping Song et al.
Youwei Wang et al.
Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise ...
Heterogeneity, self-renewal, and differentiation of hematopoietic stem cells [0.03%]
造血干细胞的异质性、自我更新及分化
Roland Jurecic,Linheng Li,R Keith Humphries
Roland Jurecic
Hatim Thaker,Arun K Sharma
Hatim Thaker
The need for a consistent therapeutic approach to tendon injury repair is long overdue. Patients with tendon microtears or full ruptures are eligible for a wide range of invasive and non invasive interventions, often subjectively decided by...
Sally A Boxall,Elena Jones
Sally A Boxall
Given the observed efficacy of culture-expanded multipotential stromal cells, also termed mesenchymal stem cells (MSCs), in the treatment of graft-versus host and cardiac disease, it remains surprising that purity and potency characterizati...