The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research [0.03%]
扁形虫Macrostomum lignano作为离子通道和干细胞研究的强大模型生物体
Daniil Simanov,Imre Mellaart-Straver,Irina Sormacheva et al.
Daniil Simanov et al.
Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in re...
Bruno P Carreira,Caetana M Carvalho,Inês M Araújo
Bruno P Carreira
The finding that neural stem cells (NSCs) are able to divide, migrate, and differentiate into several cellular types in the adult brain raised a new hope for restorative neurology. Nitric oxide (NO), a pleiotropic signaling molecule in the ...
Ethical implications in the use of embryonic and adult neural stem cells [0.03%]
胚胎和成人神经干细胞使用的伦理问题探讨
Rodrigo Ramos-Zúñiga,Oscar González-Pérez,Ana Macías-Ornelas et al.
Rodrigo Ramos-Zúñiga et al.
The advent and growth of technological advances have led to new routes of knowledge. Thereby, we currently face new challenges. We have just started to get a glimpse of the structural and functional role of neural stem cells in differentiat...
The insulin regulatory network in adult hippocampus and pancreatic endocrine system [0.03%]
成人海马和胰腺内分泌系统的胰岛素调控网络
Masanao Machida,Shin Fujimaki,Ryo Hidaka et al.
Masanao Machida et al.
There is a very strong correlation between the insulin-mediated regulatory system of the central nervous system and the pancreatic endocrine system. There are many examples of the same transcriptional factors being expressed in both regions...
Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy [0.03%]
细胞编程和重编程：塑造多巴胺神经元的细胞命运以用于细胞治疗
Julio C Aguila,Eva Hedlund,Rosario Sanchez-Pernaute
Julio C Aguila
Pluripotent stem cells are regarded as a promising cell source to obtain human dopamine neurons in sufficient amounts and purity for cell replacement therapy. Importantly, the success of clinical applications depends on our ability to steer...
Shawn C Maloney,Emilia Antecka,Alexandre N Odashiro et al.
Shawn C Maloney et al.
Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function d...
Nanako Kawaguchi,Emiko Hayama,Yoshiyuki Furutani et al.
Nanako Kawaguchi et al.
An in vitro heart disease model is a promising model used for identifying the genes responsible for the disease, evaluating the effects of drugs, and regenerative medicine. We were interested in disease models using a patient-induced plurip...
Basic biology and clinical application of multipotent mesenchymal stromal cells: from bench to bedside [0.03%]
多能间充质基质细胞的基础生物学及其临床应用：从实验室到床边
Selim Kuçi,Reinhard Henschler,Ingo Müller et al.
Selim Kuçi et al.
Mariya P Dobreva,Larissa Lhoest,Paulo N G Pereira et al.
Mariya P Dobreva et al.
Tracing the precise developmental origin of amnion and amnion-derived stem cells is still challenging and depends chiefly on analyzing powerful genetic model amniotes like mouse. Profound understanding of the fundamental differences in amni...
Functional multipotency of stem cells: what do we need from them in the heart? [0.03%]
干细胞的功能多能性：在心脏中我们需要什么？
Pablo Díez Villanueva,Ricardo Sanz-Ruiz,Alberto Núñez García et al.
Pablo Díez Villanueva et al.
After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. Randomized clinical trials have demonstrated that stem cell ...