GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma [0.03%]
GADD45β决定人胚癌细胞侧群化学抗药性和侵袭性生长
Toshihiko Inowa,Keiichi Hishikawa,Yumi Matsuzaki et al.
Toshihiko Inowa et al.
Side population (SP) cells are an enriched population of stem, and the existence of SP cells has been reported in human cancer cell lines. In this study, we performed an SP analysis using 11 human cancer cell lines and confirmed the presenc...
PKG and PKC Are Down-Regulated during Cardiomyocyte Differentiation from Embryonic Stem Cells: Manipulation of These Pathways Enhances Cardiomyocyte Production [0.03%]
蛋白激酶C和蛋白激酶C在胚胎干细胞分化为心肌细胞过程中表达下调：调控这些通路可增强心肌细胞的产生
Stephen Mobley,Jessica M Shookhof,Kara Foshay et al.
Stephen Mobley et al.
Understanding signal transduction mechanisms that drive differentiation of adult or embryonic stem cells (ESCs) is imperative if they are to be used to cure disease. While the list of signaling pathways regulating stem cell differentiation ...
Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy [0.03%]
凋亡性贫血小鼠模型骨髓Sca-1阳性造血干细胞的流式细胞仪分析及扫描电镜观察比较研究
Sumanta Chatterjee,Pratima Basak,Prosun Das et al.
Sumanta Chatterjee et al.
Self-renewing Hematopoietic Stem Cells (HSCs) are responsible for reconstitution of all blood cell lineages. Sca-1 is the "stem cell antigen" marker used to identify the primitive murine HSC population, the expression of which decreases upo...
Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells [0.03%]
通过调节鼠胚胎干细胞中GATA转录因子改变分化潜能
Callinice D Capo-Chichi,Jennifer L Smedberg,Malgorzata Rula et al.
Callinice D Capo-Chichi et al.
Background. Mouse embryonic stem (ES) cells can be differentiated in vitro by aggregation and/or retinoic acid (RA) treatment. The principal differentiation lineage in vitro is extraembryonic primitive endoderm. Dab2, Laminin, GATA4, GATA5,...
Acceleration of functional maturation and differentiation of neonatal porcine islet cell monolayers shortly in vitro cocultured with microencapsulated sertoli cells [0.03%]
微囊化的支持细胞短期内共培养可加速新生猪胰岛单层细胞的体外功能成熟和分化
Francesca Mancuso,Mario Calvitti,Giovanni Luca et al.
Francesca Mancuso et al.
The limited availability of cadaveric human donor pancreata as well as the incomplete success of the Edmonton protocol for human islet allografts fasten search for new sources of insulin the producing cells for substitution cell therapy of ...
Enhanced engraftment of a very low-dose cord blood unit in an adult haemopoietic transplant by addition of six mismatched viable cord units [0.03%]
通过添加六个错配的活脐血单位增强成人造血移植中极低剂量脐血单元植入率
Stephen J Proctor,Catherine E Chapman,Rachel Sharples et al.
Stephen J Proctor et al.
The report describes the feasibility of the addition of multiple viable HLA-mismatched unrelated cord blood units, to a low cell number matched unrelated cord, to assist clinical engraftment. An ablative stem cell transplant was performed i...
Case Reports
Stem cells international. 2010:2010:431909. DOI:10.4061/2010/431909 2010
Phases 1-3 clinical trials using adult stem cells in osteonecrosis and nonunion fractures [0.03%]
骨坏死和骨折不愈合的成人干细胞1-3期临床试验
Jean-Philippe Hauzeur,Valérie Gangji
Jean-Philippe Hauzeur
NONUNION FRACTURES AND ASEPTIC BONE NECROSIS ARE TWO PATHOLOGICAL CONDITIONS HAVING SOME IMPAIRMENT OF THE CELLULAR PART OF THE REPAIR: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies...
Progenitor cell therapy for the treatment of central nervous system injury: a review of the state of current clinical trials [0.03%]
中枢神经系统损伤的祖细胞治疗：目前临床试验现状综述
Peter A Walker,Matthew T Harting,Shinil K Shah et al.
Peter A Walker et al.
Recent preclinical work investigating the role of progenitor cell therapies for central nervous system (CNS) injuries has shown potential neuroprotection in the setting of traumatic brain injury (TBI), spinal cord injury (SCI), and ischemic...
Stem cell-based therapies for liver diseases: state of the art and new perspectives [0.03%]
基于干细胞的肝病治疗：现状与新视角
Anna Chiara Piscaglia,Mariachiara Campanale,Antonio Gasbarrini et al.
Anna Chiara Piscaglia et al.
Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyt...