DMSO-Free Programmed Cryopreservation of Fully Dissociated and Adherent Human Induced Pluripotent Stem Cells [0.03%]
无DMSO程序化冷冻保存完全解离和贴壁的人诱导多能干细胞
Igor I Katkov,Natalia G Kan,Flavio Cimadamore et al.
Igor I Katkov et al.
THREE MODES FOR CRYOPRESERVATION (CP) OF HUMAN IPSC CELLS HAVE BEEN COMPARED: STD: standard CP of small clumps with 10% of CPA in cryovials, ACC: dissociation of the cells with Accutase and freezing in cryovials, and PLT: programmed freezin...
Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes? [0.03%]
代谢综合征、脂毒性及衰老是间充质干细胞衰竭综合征吗？
Eduardo Mansilla,Vanina Díaz Aquino,Daniel Zambón et al.
Eduardo Mansilla et al.
One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism i...
Derivation of two new human embryonic stem cell lines from nonviable human embryos [0.03%]
从不可存活的人类胚胎中分离出两个新的人类胚胎干细胞系
Svetlana Gavrilov,Darja Marolt,Nataki C Douglas et al.
Svetlana Gavrilov et al.
We report the derivation and characterization of two new human embryonic stem cells (hESC) lines (CU1 and CU2) from embryos with an irreversible loss of integrated organismic function. In addition, we analyzed retrospective data of morpholo...
Hiroto Narimatsu
Hiroto Narimatsu
Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT inc...
Catriona Kelly,Cara C S Flatt,Neville H McClenaghan
Catriona Kelly
The incidence of diabetes and the associated debilitating complications are increasing at an alarming rate worldwide. Current therapies for type 1 diabetes focus primarily on administration of exogenous insulin to help restore glucose homeo...
Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt [0.03%]
基因修饰成人造血干细胞治疗艾滋病的I/II期临床试验：经验教训
Ronald T Mitsuyasu,Jerome A Zack,Janet L Macpherson et al.
Ronald T Mitsuyasu et al.
Gene therapy for individuals infected with HIV has the potential to provide a once-only treatment that will act to reduce viral load, preserve the immune system, and mitigate cumulative toxicities associated with highly active antiretrovira...
Human motor neuron progenitor transplantation leads to endogenous neuronal sparing in 3 models of motor neuron loss [0.03%]
人源运动神经元前体细胞移植在三种运动神经元丢失模型中可保护内源性神经元
Tanya J Wyatt,Sharyn L Rossi,Monica M Siegenthaler et al.
Tanya J Wyatt et al.
Motor neuron loss is characteristic of many neurodegenerative disorders and results in rapid loss of muscle control, paralysis, and eventual death in severe cases. In order to investigate the neurotrophic effects of a motor neuron lineage g...
Risk factors and options to improve engraftment in unrelated cord blood transplantation [0.03%]
无关脐带血移植的影响因素及提高植入率的策略分析
Anna D Petropoulou,Vanderson Rocha
Anna D Petropoulou
Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor. UCB present many advantages over bone marrow or mobilize...
Chandana Tekkatte,Gency Ponrose Gunasingh,K M Cherian et al.
Chandana Tekkatte et al.
Cellular therapy is reaching a pinnacle with an understanding of the potential of human mesenchymal stem cells (hMSCs) to regenerate damaged tissue in the body. The limited numbers of these hMSCs in currently identified sources, like bone m...
The role of glucose, serum, and three-dimensional cell culture on the metabolism of bone marrow-derived mesenchymal stem cells [0.03%]
葡萄糖、血清及三维培养对骨髓间充质干细胞代谢的影响
Byron Deorosan,Eric A Nauman
Byron Deorosan
Mesenchymal stem cells (MSCs) have become a critical addition to all facets of tissue engineering. While most in vitro research has focused on their behavior in two-dimensional culture, relatively little is known about the cells' behavior i...