Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box [0.03%]
干细胞治疗急性心肌梗死：金锅还是潘多拉魔盒？
V K Shah,K K Shalia
V K Shah
Stem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing. Stem cells from various sources, including heart itself in preclinical and animal studies, have shown the po...
Expression patterns of cancer-testis antigens in human embryonic stem cells and their cell derivatives indicate lineage tracks [0.03%]
人胚胎干细胞及其细胞衍生物中癌症睾丸抗原的表达模式表明了谱系特征
Nadya Lifantseva,Anna Koltsova,Tatyana Krylova et al.
Nadya Lifantseva et al.
Pluripotent stem cells can differentiate into various lineages but undergo genetic and epigenetic changes during long-term cultivation and, therefore, require regular monitoring. The expression patterns of cancer-testis antigens (CTAs) MAGE...
Takashi Hiroyama,Kenichi Miharada,Ryo Kurita et al.
Takashi Hiroyama et al.
The supply of transfusable red blood cells (RBCs) is not sufficient in many countries. If transfusable RBCs could be produced abundantly from certain resources, it would be very useful. Our group has developed a method to produce enucleated...
Parinya Noisa,Rangsun Parnpai
Parinya Noisa
It has long been discovered that human pluripotent cells could be isolated from the blastocyst state of embryos and called human embryonic stem cells (ESCs). These cells can be adapted and propagated indefinitely in culture in an undifferen...
Outi M Villet,Antti Siltanen,Tommi Pätilä et al.
Outi M Villet et al.
The overall objective of cell transplantation is to repopulate postinfarction scar with contractile cells, thus improving systolic function, and to prevent or to regress the remodeling process. Direct implantation of isolated myoblasts, car...
Clara Y Cheong,Thomas Lufkin
Clara Y Cheong
Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. In alignment with our present understanding on the genetic, prote...
Marta Isabel Pereira,Artur Paiva
Marta Isabel Pereira
Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells derived from hematopoietic progenitors that bridge the transition between the innate and adaptive immune responses, while maintaining self-tolerance and Th1/Th...
Ren Mingliang,Zhang Bo,Wang Zhengguo
Ren Mingliang
Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many cli...
Serpen Durnaoglu,Sermin Genc,Kursad Genc
Serpen Durnaoglu
Many human neurological diseases are not currently curable and result in devastating neurologic sequelae. The increasing availability of induced pluripotent stem cells (iPSCs) derived from adult human somatic cells provides new prospects fo...
Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation [0.03%]
间充质干细胞的表观遗传调控：以成骨和成脂分化为重点
Chad M Teven,Xing Liu,Ning Hu et al.
Chad M Teven et al.
Stem cells are characterized by their capability to self-renew and terminally differentiate into multiple cell types. Somatic or adult stem cells have a finite self-renewal capacity and are lineage-restricted. The use of adult stem cells fo...