Shi-Jiang Lu,Randall J Lee,Claudio Napoli et al.
Shi-Jiang Lu et al.
The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia [0.03%]
β-地中海贫血基于造血干细胞的基因治疗面临的挑战
Ekati Drakopoulou,Eleni Papanikolaou,Nicholas P Anagnou
Ekati Drakopoulou
β-thalassemia is characterized by reduced or absence of β-globin production, resulting in anemia. Current therapies include blood transfusion combined with iron chelation. BM transplantation, although curative, is restricted by the matche...
Spleen as a site for hematopoiesis of a distinct antigen presenting cell type [0.03%]
脾脏作为一种特殊抗原递呈细胞类型的造血器官
Helen C O&#x;Neill,Kristin L Griffiths,Pravin Periasamy et al.
Helen C O&#x;Neill et al.
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen ...
Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report [0.03%]
有关骨髓来源的间质基质细胞通过鼻腔给药后在受损小鼠脑内的检测：一份告诫报告
Elena H Chartoff,Diane Damez-Werno,Kai C Sonntag et al.
Elena H Chartoff et al.
Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport of MSCs to the brain. Howeve...
Osteoblastic and vascular endothelial niches, their control on normal hematopoietic stem cells, and their consequences on the development of leukemia [0.03%]
骨形成细胞和血管内皮细胞生态位对正常造血干细胞的调控及其在白血病发生发展中的作用
Bella S Guerrouahen,Ibrahim Al-Hijji,Arash Rafii Tabrizi
Bella S Guerrouahen
Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called "niches." The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differenti...
Gabriela Kania,Kenneth R Boheler,Ulf Landmesser et al.
Gabriela Kania et al.
Umile Giuseppe Longo,Alfredo Lamberti,Stefano Petrillo et al.
Umile Giuseppe Longo et al.
Tissue engineering techniques using novel scaffold materials offer potential alternatives for managing tendon disorders. Tissue engineering strategies to improve tendon repair healing include the use of scaffolds, growth factors, cell seedi...
Lawrence V Gulotta,Salma Chaudhury,Daniel Wiznia
Lawrence V Gulotta
Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing...
Generation and characterization of erythroid cells from human embryonic stem cells and induced pluripotent stem cells: an overview [0.03%]
人胚胎干细胞和诱导多能干细胞生成及红细胞表征的概述
Kai-Hsin Chang,Halvard Bonig,Thalia Papayannopoulou
Kai-Hsin Chang
Because of the imbalance in the supply and demand of red blood cells (RBCs), especially for alloimmunized patients or patients with rare blood phenotypes, extensive research has been done to generate therapeutic quantities of mature RBCs fr...
Fuliang Du,Mark G Carter,Giorgio A Presicce et al.
Fuliang Du et al.