Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage [0.03%]
小分子可大幅提高人诱导多能干细胞向神经系分化的效率
Sally K Mak,Y Anne Huang,Shifteh Iranmanesh et al.
Sally K Mak et al.
Efficient in vitro differentiation into specific cell types is more important than ever after the breakthrough in nuclear reprogramming of somatic cells and its potential for disease modeling and drug screening. Key success factors for neur...
Bilateral transplantation of allogenic adult human bone marrow-derived mesenchymal stem cells into the subventricular zone of Parkinson's disease: a pilot clinical study [0.03%]
人骨髓间充质干细胞双侧移植至帕金森病纹状体的临床研究试点观察
N K Venkataramana,Rakhi Pal,Shailesh A V Rao et al.
N K Venkataramana et al.
The progress of PD and its related disorders cannot be prevented with the medications available. In this study, we recruited 8 PD and 4 PD plus patients between 5 to 15 years after diagnosis. All patients received BM-MSCs bilaterally into t...
Mesenchymal stem cell for prevention and management of intervertebral disc degeneration [0.03%]
间充质干细胞在椎间盘退变的预防和治疗中的作用
Umile Giuseppe Longo,Nicola Papapietro,Stefano Petrillo et al.
Umile Giuseppe Longo et al.
Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, althoug...
Chih-Hao Kuo,Shao-Yao Ying
Chih-Hao Kuo
The use of somatic cells to generate induced-pluripotent stem cells (iPSCs), which have gene characteristic resembling those of human embryonic stem cells (hESCs), has opened up a new avenue to produce patient-specific stem cells for regene...
Notch regulation of hematopoiesis, endothelial precursor cells, and blood vessel formation: orchestrating the vasculature [0.03%]
诺特赫调节造血作用、内皮前体细胞和血管形成：协调血管生成
Vincenza Caolo,Daniel G M Molin,Mark J Post
Vincenza Caolo
The development of the vascular system begins with the formation of hemangioblastic cells, hemangioblasts, which organize in blood islands in the yolk sac. The hemangioblasts differentiate into hematopoietic and angioblastic cells. Subseque...
Analysis of embryoid bodies derived from human induced pluripotent stem cells as a means to assess pluripotency [0.03%]
人诱导多能干细胞系的胚胎体分析及其多能性评估
Steven D Sheridan,Vasudha Surampudi,Raj R Rao
Steven D Sheridan
Human induced pluripotent stem cells (hiPSCs) have core properties of unlimited self-renewal and differentiation potential and have emerged as exciting cell sources for applications in regenerative medicine, drug discovery, understanding of...
Jens Folke Kiilgaard,Erik Scherfig,Jan Ulrik Prause et al.
Jens Folke Kiilgaard et al.
Purpose: To investigate the effect of transplanted amniotic membrane (AM) on subretinal wound healing. Methods: Nine Danish Landrace pi...
Assessment of hereditary retinal degeneration in the English springer spaniel dog and disease relationship to an RPGRIP1 mutation [0.03%]
评估英国春田犬遗传性视网膜变性和与RPGRIP1突变的关系
Kristina Narfström,Manbok Jeong,Jennifer Hyman et al.
Kristina Narfström et al.
Intensive breeding and selection on desired traits have produced high rates of inherited diseases in dogs. Hereditary retinal degeneration, often called progressive retinal atrophy (PRA), is prevalent in dogs with disease entities comparabl...
Skin-derived precursor cells as an in vitro modelling tool for the study of type 1 neurofibromatosis [0.03%]
皮肤源性前体细胞作为I型神经纤维瘤病的体外建模工具
Araika Gutiérrez-Rivera,Haizea Iribar,Anna Tuneu et al.
Araika Gutiérrez-Rivera et al.
The most characteristic feature of neurofibromatosis type 1 (NF1) is the development of neurofibromas. It has been suggested that these tumors are caused by somatic inactivation of the wild-type NF1 allele, but the cell that originally suff...
Leonhard Linta,Marianne Stockmann,Tobias M Boeckers et al.
Leonhard Linta et al.
α-synuclein is a protein involved in the pathogenesis of several so-called synucleinopathies including Parkinson's disease. A variety of models have been so far assessed. Human induced pluripotent stem cells provide a patient- and disease-...