Annexin A2 at the interface of actin and membrane dynamics: a focus on its roles in endocytosis and cell polarization [0.03%]
肌动蛋白与膜动力学界面的 annexin a2：其在内吞作用和细胞极化中的作用研究
Adam G Grieve,Stephen E Moss,Matthew J Hayes
Adam G Grieve
Annexins are a family of calcium- and phospholipid-binding proteins found in nearly all eukaryotes. They are structurally highly conserved and have been implicated in a wide range of cellular activities. In this paper, we focus on Annexin A...
David G Menter,Raymond N Dubois
David G Menter
Prostaglandins exert a profound influence over the adhesive, migratory, and invasive behavior of cells during the development and progression of cancer. Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E(2) synthase-1 (mPGES-1) are upr...
Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins [0.03%]
癌细胞粘附和转移：选择素、整合素以及肝素的抑制潜能
Gerd Bendas,Lubor Borsig
Gerd Bendas
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leuko...
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells [0.03%]
人类癌细胞中不同miRNA的亚细胞分布及表达特征大小模式
Beibei Chen,Bo Zhang,Huaxia Luo et al.
Beibei Chen et al.
Introduction. Small noncoding RNAs have important regulatory functions in different cell pathways. It is believed that most of them mainly play role in gene post-transcriptional regulation in the cytoplasm. Recent evidence suggests miRNA an...
PKC-Mediated ZYG1 Phosphorylation Induces Fusion of Myoblasts as well as of Dictyostelium Cells [0.03%]
PKC介导的ZYG1磷酸化诱导肌管以及Dictyostelium细胞融合
Aiko Amagai,Harry Macwilliams,Takahiro Isono et al.
Aiko Amagai et al.
We have previously demonstrated that a novel protein ZYG1 induces sexual cell fusion (zygote formation) of Dictyostelium cells. In the process of cell fusion, involvements of signal transduction pathways via Ca(2+) and PKC (protein kinase C...
KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts [0.03%]
卡波西肉瘤病毒编码的microRNA：对病毒致癌机制和新概念的启示
Zhiqiang Qin,Andrew Jakymiw,Victoria Findlay et al.
Zhiqiang Qin et al.
The human genome contains microRNAs (miRNAs), small noncoding RNAs that orchestrate a number of physiologic processes through regulation of gene expression. Burgeoning evidence suggests that dysregulation of miRNAs may promote disease progr...
Fiona J Pixley
Fiona J Pixley
Macrophages are terminally differentiated cells of the mononuclear phagocytic lineage and develop under the stimulus of their primary growth and differentiation factor, CSF-1. Although they differentiate into heterogeneous populations, depe...
Effects of Cisplatin in neuroblastoma rat cells: damage to cellular organelles [0.03%]
顺铂对神经母细胞瘤大鼠细胞的作用：对细胞器的损害
Giada Santin,Luigi Scietti,Paola Veneroni et al.
Giada Santin et al.
Cisplatin (cisPt) is a chemotherapy agent used as a treatment for several types of cancer. The main cytotoxic effect of cisplatin is generally accepted to be DNA damage. Recently, the mechanism by which cisPt generates the cascade of events...
Takeshi Noda,Shun Kageyama,Naonobu Fujita et al.
Takeshi Noda et al.
Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing wi...
Yong-Nyun Kim,Kyung Hee Koo,Jee Young Sung et al.
Yong-Nyun Kim et al.
Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic proces...