Andreas Till,Ronak Lakhani,Sarah F Burnett et al.
Andreas Till et al.
Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells. Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain ...
Jimmie E Fata,Shawon Debnath,Edmund C Jenkins Jr et al.
Jimmie E Fata et al.
A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force i...
Rajat Singh,Ana Maria Cuervo
Rajat Singh
Lipid droplets (LDs), initially considered "inert" lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which t...
Katrin Juenemann,Eric A Reits
Katrin Juenemann
Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for deliver...
Antiproliferative factor-induced changes in phosphorylation and palmitoylation of cytoskeleton-associated protein-4 regulate its nuclear translocation and DNA binding [0.03%]
抗增殖因子通过调节细胞骨架相关蛋白4的磷酸化和棕榈酰化调控其核转位及DNA结合能力
David A Zacharias,Matthew Mullen,Sonia Lobo Planey
David A Zacharias
Cytoskeleton-associated protein 4 (CKAP4) is a reversibly palmitoylated and phosphorylated transmembrane protein that functions as a high-affinity receptor for antiproliferative factor (APF)-a sialoglycopeptide secreted from bladder epithel...
Aggrephagy: selective disposal of protein aggregates by macroautophagy [0.03%]
自噬介导的蛋白质聚集选择性降解机制：Aggrephagy
Trond Lamark,Terje Johansen
Trond Lamark
Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various...
Cytoskeletal interactions at the nuclear envelope mediated by nesprins [0.03%]
由nesprin介导的细胞核包膜处的细胞质骨架相互作用
Surayya Taranum,Ilknur Sur,Rolf Müller et al.
Surayya Taranum et al.
Nesprin-1 is a giant tail-anchored nuclear envelope protein composed of an N-terminal F-actin binding domain, a long linker region formed by multiple spectrin repeats and a C-terminal transmembrane domain. Based on this structure, it connec...
Corina Ciobanasu,Bruno Faivre,Christophe Le Clainche
Corina Ciobanasu
Cell-matrix adhesion plays a major role during cell migration. Proteins from adhesion structures connect the extracellular matrix to the actin cytoskeleton, allowing the growing actin network to push the plasma membrane and the contractile ...
IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells [0.03%]
酵母、Dictyostelium及哺乳动物细胞中的IQGAP家族成员
Katie B Shannon
Katie B Shannon
IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras sup...
Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis [0.03%]
整合素及其细胞外基质配体在淋巴管生成和淋巴结转移中的作用
Jie Chen,J Steven Alexander,A Wayne Orr
Jie Chen
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular ...