Fulvio Reggiori,Masaaki Komatsu,Kim Finley et al.
Fulvio Reggiori et al.
Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. The hallmark of thi...
Regina Brigelius-Flohé,Mike Müller,Doris Lippmann et al.
Regina Brigelius-Flohé et al.
The NF-E2-related factor-2 (Nrf2) is a transcription factor which regulates the major cellular defense systems and thereby contributes to the prevention of many diseases including cancer. Selenium deficiency is associated with a higher canc...
Mayumi Soga,Atsushi Matsuzawa,Hidenori Ichijo
Mayumi Soga
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38. ASK1 is activated by various types of stress, such as oxidati...
S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function [0.03%]
蛋白质二硫键异构酶的S-谷胱甘肽化通过调节雌激素受体α稳定性来调控雌激素受体α功能
Ying Xiong,Yefim Manevich,Kenneth D Tew et al.
Ying Xiong et al.
S-Glutathionylation of cysteine residues within target proteins is a posttranslational modification that alters structure and function. We have shown that S-glutathionylation of protein disulfide isomerase (PDI) disrupts protein folding and...
MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network [0.03%]
Nbr1自噬受体FW结构域与微管网络之间的MAP1B相互作用促进其关联
Katie Marchbank,Sarah Waters,Roland G Roberts et al.
Katie Marchbank et al.
Selective autophagy is a process whereby specific targeted cargo proteins, aggregates, or organelles are sequestered into double-membrane-bound phagophores before fusion with the lysosome for protein degradation. It has been demonstrated th...
Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells [0.03%]
人多能干细胞源心肌细胞的力学性能影响其收缩功能
Laurie B Hazeltine,Chelsey S Simmons,Max R Salick et al.
Laurie B Hazeltine et al.
Human pluripotent stem cell (hPSC-) derived cardiomyocytes have potential applications in drug discovery, toxicity testing, developmental studies, and regenerative medicine. Before these cells can be reliably utilized, characterization of t...
A Micro-RNA Connection in BRaf(V600E)-Mediated Premature Senescence of Human Melanocytes [0.03%]
微小核糖核酸与B-raf(V600E)诱导人类黑素细胞过早衰老之间的关系
Gang Ren,Jingwei Feng,Ila Datar et al.
Gang Ren et al.
Recent high-throughput-sequencing of the cancer genome has identified oncogenic mutations in BRaf genetic locus as one of the critical events in melanomagenesis. In normal cells, the activity of BRaf is tightly regulated. Gain-of-function m...
Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction [0.03%]
核膜和细胞骨架的解离：源自相同细胞功能障碍的不同生物性肌张力不全
Nadia A Atai,Scott D Ryan,Rashmi Kothary et al.
Nadia A Atai et al.
Most cases of early onset DYT1 dystonia in humans are caused by a GAG deletion in the TOR1A gene leading to loss of a glutamic acid (ΔE) in the torsinA protein, which underlies a movement disorder associated with neuronal dysfunction witho...
Potential role of drebrin a, an f-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: functional implications in epilepsy [0.03%]
drebrin A（一种F-肌动蛋白结合蛋白）在毛果芸香碱诱导的癫痫发作后的反应性突触可塑性中的潜在作用及其在癫痫发病机制中的功能意义
Lotfi Ferhat
Lotfi Ferhat
Several neurological disorders characterized by cognitive deficits, including Alzheimer's disease, down syndrome, and epilepsy exhibit abnormal spine density and/or morphology. Actin-based cytoskeleton network dynamics is critical for the r...
ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer [0.03%]
脑缺血期间的内质网-线粒体相互作用：分子伴侣和内质网-线粒体钙转移
Yi-Bing Ouyang,Rona G Giffard
Yi-Bing Ouyang
It is commonly believed that sustained elevations in the mitochondrial matrix Ca(2+) concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia. The physical association between the endoplasmic ...