Endothelial cells and astrocytes: a concerto en duo in ischemic pathophysiology [0.03%]
血管内皮细胞与星形胶质细胞在缺血病理生理过程中的相互作用
Vincent Berezowski,Andrew M Fukuda,Roméo Cecchelli et al.
Vincent Berezowski et al.
The neurovascular/gliovascular unit has recently gained increased attention in cerebral ischemic research, especially regarding the cellular and molecular changes that occur in astrocytes and endothelial cells. In this paper we summarize th...
Effects of IGF-1 on I(K) and I(K1) Channels via PI3K/Akt Signaling in Neonatal Cardiac Myocytes [0.03%]
IGF-1通过PI3K/Akt信号途径对新生心肌细胞IK和IK1通道的影响
Richard M Millis,Zikiar V Alvin,Aiqiu Zhao et al.
Richard M Millis et al.
Previous studies suggest that sarcolemmal potassium currents play important roles in cardiac hypertrophy. IGF-1 contributes to cardiac hypertrophy via activation of PI3K/Akt signaling. However, the relationships between IGF-1, PI3K/Akt sign...
Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? [0.03%]
氧化应激、DNA损伤和c-Abl信号传导：在神经退行性疾病中的交汇点？
Stefania Gonfloni,Emiliano Maiani,Claudia Di Bartolomeo et al.
Stefania Gonfloni et al.
The c-Abl tyrosine kinase is implicated in diverse cellular activities including growth factor signaling, cell adhesion, oxidative stress, and DNA damage response. Studies in mouse models have shown that the kinases of the c-Abl family play...
Ross B Mounsey,Peter Teismann
Ross B Mounsey
Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have been found in the brains of patients of numerous neurodegenerative disorders, including Parkinson's disease (PD). The pathogenesis of PD is large...
Glutathione in cerebral microvascular endothelial biology and pathobiology: implications for brain homeostasis [0.03%]
谷胱甘肽在脑微血管内皮细胞生物学和病理生物学中的作用：对脑稳态的意义
Wei Li,Carmina Busu,Magdalena L Circu et al.
Wei Li et al.
The integrity of the vascular endothelium of the blood-brain barrier (BBB) is central to cerebrovascular homeostasis. Given the function of the BBB as a physical and metabolic barrier that buffers the systemic environment, oxidative damage ...
Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival [0.03%]
神经元中的氧化性DNA损伤及其在神经元稳态和存活中Ku的作用
Daniela De Zio,Matteo Bordi,Francesco Cecconi
Daniela De Zio
Oxidative DNA damage is produced by reactive oxygen species (ROS) which are generated by exogenous and endogenous sources and continuously challenge the cell. One of the most severe DNA lesions is the double-strand break (DSB), which is mai...
Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells [0.03%]
PC12细胞分裂过程中分泌颗粒的分割和胞外排泄
Nickolay Vassilev Bukoreshtliev,Erlend Hodneland,Tilo Wolf Eichler et al.
Nickolay Vassilev Bukoreshtliev et al.
The biogenesis, maturation, and exocytosis of secretory granules in interphase cells have been well documented, whereas the distribution and exocytosis of these hormone-storing organelles during cell division have received little attention....
Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species [0.03%]
神经元细胞线粒体能量代谢的动态模型：α-酮戊二酸脱氢酶活性下降对ATP生成和活性氧簇产生影响的研究
Nikolaus Berndt,Sascha Bulik,Hermann-Georg Holzhütter
Nikolaus Berndt
Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity ...
Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration [0.03%]
脑内一氧化氮失活机制：生物能量学和神经退行性病变中的作用
Ricardo M Santos,Cátia F Lourenço,Ana Ledo et al.
Ricardo M Santos et al.
During the last decades nitric oxide ((•)NO) has emerged as a critical physiological signaling molecule in mammalian tissues, notably in the brain. (•)NO may modify the activity of regulatory proteins via direct reaction with the heme moi...
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers [0.03%]
阿尔茨海默病中的线粒体和内质网相关氧化应激：从发病机制到生物标志物
E Ferreiro,I Baldeiras,I L Ferreira et al.
E Ferreiro et al.
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting several million of people worldwide. Pathological changes in the AD brain include the presence of amyloid plaques, neurofibrillary tangles, loss of neur...