Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process [0.03%]
IKK-NF-κB信号调控的自噬的上下调及其对衰老进程的影响
Antero Salminen,Juha M T Hyttinen,Anu Kauppinen et al.
Antero Salminen et al.
The NF-κB signaling system and the autophagic degradation pathway are crucial cellular survival mechanisms, both being well conserved during evolution. Emerging studies have indicated that the IKK/NF-κB signaling axis regulates autophagy ...
Simone Cardaci,Maria Rosa Ciriolo
Simone Cardaci
Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to...
Caloric Restriction and the Nutrient-Sensing PGC-1α in Mitochondrial Homeostasis: New Perspectives in Neurodegeneration [0.03%]
热量限制与营养感应PGC-1α在线粒体稳态中的作用：神经退行性病变的新视角
Daniele Lettieri Barbato,Sara Baldelli,Beatrice Pagliei et al.
Daniele Lettieri Barbato et al.
Mitochondrial activity progressively declines during ageing and in many neurodegenerative diseases. Caloric restriction (CR) has been suggested as a dietary intervention that is able to postpone the detrimental aspects of aging as it amelio...
Rodney P Guttmann,Tamara J Powell
Rodney P Guttmann
Evidence of increased oxidative stress has been found in various neurodegenerative diseases and conditions. While it is unclear whether oxidative stress is a cause or effect, protein, lipid, and DNA have all been found to be susceptible to ...
Targeting metabolism and autophagy in the context of haematologic malignancies [0.03%]
血液系统恶性肿瘤中靶向代谢和自噬
Versha Banerji,Spencer B Gibson
Versha Banerji
Autophagy is a cellular process that maintains the homeostasis of the normal cell. It not only allows for cell survival in times of metabolic stress with nutrient recycling but also is able to lead to cell death when required. During malign...
WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation [0.03%]
WIPI-1阳性自噬体样囊泡捕获致病性金黄色葡萄球菌进行溶酶体降解
Mario Mauthe,Wenqi Yu,Oleg Krut et al.
Mario Mauthe et al.
Invading pathogens provoke the autophagic machinery and, in a process termed xenophagy, the host cell survives because autophagy is employed as a safeguard for pathogens that escaped phagosomes. However, some pathogens can manipulate the au...
The Chemical Interplay between Nitric Oxide and Mitochondrial Cytochrome c Oxidase: Reactions, Effectors and Pathophysiology [0.03%]
一氧化氮与线粒体细胞色素c氧化酶之间的化学作用：反应、效应器及病理生理学
Paolo Sarti,Elena Forte,Alessandro Giuffrè et al.
Paolo Sarti et al.
Nitric oxide (NO) reacts with Complex I and cytochrome c oxidase (CcOX, Complex IV), inducing detrimental or cytoprotective effects. Two alternative reaction pathways (PWs) have been described whereby NO reacts with CcOX, producing either a...
Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases [0.03%]
线粒体动力学在癌症和神经退行性和神经炎症性疾病中的作用
Mauro Corrado,Luca Scorrano,Silvia Campello
Mauro Corrado
Mitochondria are key organelles in the cell, hosting essential functions, from biosynthetic and metabolic pathways, to oxidative phosphorylation and ATP production, from calcium buffering to red-ox homeostasis and apoptotic signalling pathw...
Pamela Boon Li Pun,Michael P Murphy
Pamela Boon Li Pun
Glycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing. Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation. Because the...
Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone [0.03%]
美沙酮诱导SH-SY5Y细胞钙离子信号紊乱的药理学特征研究
Sergio Perez-Alvarez,Maria E Solesio,Maria D Cuenca-Lopez et al.
Sergio Perez-Alvarez et al.
Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed calcium deregulation (DCD). In this study, we show that, in terms of their Ca(2+) r...