Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance [0.03%]
细胞骨架蛋白的核质穿梭：分子机制及生物学意义
Masahiro Kumeta,Shige H Yoshimura,James Hejna et al.
Masahiro Kumeta et al.
Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes. Nucl...
Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation [0.03%]
由Tenascin-C衍生的肽对肿瘤细胞存活、增殖及分化的影响及其β1整合素激活的意义
Takuya Iyoda,Fumio Fukai
Takuya Iyoda
Cell adhesion to extracellular matrix (ECM) participates in various biological processes, such as cell survival, proliferation, differentiation, and migration. Since these processes are essential for keeping homeostasis, aberration of these...
The actin-bundling protein L-plastin: a critical regulator of immune cell function [0.03%]
肌动蛋白束集蛋白L- plastin：一个免疫细胞功能的重要调节因子
Sharon Celeste Morley
Sharon Celeste Morley
L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein ...
Beina Teng,Alexander Lukasz,Mario Schiffer
Beina Teng
ADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin c...
Alexander J S Choi,Stefan W Ryter
Alexander J S Choi
Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabo...
When Cells Suffocate: Autophagy in Cancer and Immune Cells under Low Oxygen [0.03%]
当细胞窒息时：低氧条件下癌细胞和免疫细胞的自噬作用
Katrin Schlie,Jaeline E Spowart,Luke R K Hughson et al.
Katrin Schlie et al.
Hypoxia is a signature feature of growing tumors. This cellular state creates an inhospitable condition that impedes the growth and function of all cells within the immediate and surrounding tumor microenvironment. To adapt to hypoxia, cell...
HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth [0.03%]
HIC-5：一个移动分子支架，可调控细胞生长的依附依赖性
Motoko Shibanuma,Kazunori Mori,Kiyoshi Nose
Motoko Shibanuma
HIC-5 is a multidomain LIM protein homologous to paxillin that serves as a molecular scaffold at focal adhesions and in the nucleus. It forms mobile molecular units with LIM-only proteins, PINCH, and CRP2 and translocates in and out of the ...
Sejeong Shin,Laura Wolgamott,Sang-Oh Yoon
Sejeong Shin
Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent stu...
Keisuke Obara,Yoshinori Ohsumi
Keisuke Obara
Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase is an essential process in autophagy. Atg14, a specific subunit of one of the PtdIns 3-kinase complexes, targets the complex to the probable site of autophagosome formati...
Differentiation potential of pancreatic fibroblastoid cells/stellate cells: effects of peroxisome proliferator-activated receptor gamma ligands [0.03%]
胰腺纤维星状细胞分化潜能：过氧化物酶体增殖激活受体γ配体的影响
M-L Kruse,S Hopf-Jensen,C Timke et al.
M-L Kruse et al.
Pancreatic stellate cells have been investigated mostly for their activation process, supposed to support the development of pancreatic disease. Few studies have been presented on reversal of the activation process in vitro. Thiazolidinedio...