Midori Umekawa,Daniel J Klionsky
Midori Umekawa
From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding w...
Michael Föller,Lars Kaestner,Elisabetta Straface et al.
Michael Föller et al.
Makoto Nagano,Daisuke Hoshino,Naohiko Koshikawa et al.
Makoto Nagano et al.
Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. Integrins are important receptors for the ECM and form structures called focal adhesions ...
The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells [0.03%]
上皮细胞的质膜电位及其肌动蛋白细胞骨架的组织模式
Silvia Chifflet,Julio A Hernández
Silvia Chifflet
The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cel...
Forms, crosstalks, and the role of phospholipid biosynthesis in autophagy [0.03%]
自噬中的形式、跨界合作和磷脂生物合成的作用
Leanne Pereira,John Paul Girardi,Marica Bakovic
Leanne Pereira
Autophagy is a highly conserved cellular process occurring during periods of stress to ensure a cell's survival by recycling cytosolic constituents and making products that can be used in energy generation and other essential processes. Thr...
Daniel Grasso,Maria Noé Garcia,Juan L Iovanna
Daniel Grasso
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminat...
The role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis [0.03%]
免疫球蛋白超家族细胞粘附分子在癌症转移中的作用
Chee Wai Wong,Danielle E Dye,Deirdre R Coombe
Chee Wai Wong
Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconne...
Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers [0.03%]
肿瘤进展过程中细胞-基质相互作用的变化
Rajeswari Jinka,Renu Kapoor,Pavana Goury Sistla et al.
Rajeswari Jinka et al.
Cancer progression is a multistep process during which normal cells exhibit molecular changes that culminate into the highly malignant and metastatic phenotype, observed in cancerous tissues. The initiation of cell transformation is general...
Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer [0.03%]
肌动蛋白聚束蛋白家族塑形蛋白的功能：在白细胞、神经元、肠道和癌症中的作用
Hiroto Shinomiya
Hiroto Shinomiya
Sophisticated regulation of the actin cytoskeleton by a variety of actin-binding proteins is essential for eukaryotic cells to perform their diverse functions. The plastin (also know, as fimbrin) protein family belongs to actin-bundling pro...
Toshiyuki Murai
Toshiyuki Murai
Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through prote...