Jane C Caldwell,Kannan Krishnan,Marina V Evans
Jane C Caldwell
Are cosmetics used in developing countries safe? Use and dermal irritation of body care products in jimma town, southwestern ethiopia [0.03%]
发展中国家的化妆品安全吗？以埃塞俄比亚西南部吉马镇的身体护理产品使用和皮肤刺激情况为例
Wayessa Amasa,Dante Santiago,Seblework Mekonen et al.
Wayessa Amasa et al.
Background. Rabbit skin model was used to test skin irritation of the most commonly used cosmetic products in Jimma town, southwestern Ethiopia. The most commonly used cosmetics were Dove, Glysolid, College, Top Society, Fair and Lovely, Ni...
Martha L Hale,Shuowei Cai,S Ashraf Ahmed
Martha L Hale
Safety assessment of zigbir®: a polyherbal formulation in sprague-dawley rats [0.03%]
zigbir®对大鼠的安全性评价研究
Joseph Joshua Allan,Ranjit Madhukar Bhide,Amit Agarwal
Joseph Joshua Allan
The safety of Zigbir®, a polyherbal formulation intended for use as food supplement, was evaluated in Sprague-Dawley rats treated orally at the dose of 2000 mg/kg in acute and at 250, 500, and 1000 mg/kg for 90 days in subchronic toxicity ...
Yonghua Ji,Maria Elena De Lima
Yonghua Ji
Damian G Deavall,Elizabeth A Martin,Judith M Horner et al.
Damian G Deavall et al.
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their r...
Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms [0.03%]
前沿的PBPK模型与分析：未来建模工作的基础及与新兴毒理学范式的桥梁
Jane C Caldwell,Marina V Evans,Kannan Krishnan
Jane C Caldwell
Physiologically based Pharmacokinetic (PBPK) models are used for predictions of internal or target dose from environmental and pharmacologic chemical exposures. Their use in human risk assessment is dependent on the nature of databases (ani...
Andrew D Johnston,Paul R Ebert
Andrew D Johnston
Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role ...
Protective Effect of Scutellaria litwinowii Extract on Serum/Glucose-Deprived Cultured PC12 Cells and Determining the Role of Reactive Oxygen Species [0.03%]
胡黄连提取物对血清及葡萄糖剥夺培养的PC12细胞的保护作用及其抗氧化作用机制的研究
Maryam Afsharzadeh,Zahra Tayarani-Najaran,Aryo Zare et al.
Maryam Afsharzadeh et al.
Considering the wide, positive reporting of the role of reactive oxygen species in ischemic brain injury, searching for antioxidant drugs within herbal remedies is logical. In this study, the protective effects of Scutellaria litwinowii Bor...
Mining the virgin land of neurotoxicology: a novel paradigm of neurotoxic peptides action on glycosylated voltage-gated sodium channels [0.03%]
开采神经毒理学的新领域：一种新的关于神经毒性肽作用于糖基化电压门控钠通道的理论框架
Zhirui Liu,Jie Tao,Pin Ye et al.
Zhirui Liu et al.
Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on the molecular basis for action potentials (AP) in neuronal firings. Even though the structure-function studies were the most pursued spots, the posttranslation...