Targeting Nurr1 With Amodiaquine Preserves Dendritic Spines and Cognitive Function After Chronic Cerebral Hypoperfusion [0.03%]
抗疟药氯畸宁通过作用于NURR1保护慢性脑低灌注引起的树突棘和认知损伤
Xiuli Zeng,Xiaomei Xie,Junrun Zhang et al.
Xiuli Zeng et al.
Background: Nurr1, an orphan nuclear receptor that lacks an endogenous ligand, plays a key role in hippocampal function, synaptic plasticity, and cognitive processes. It is linked to various central nervous system disease...
White Matter Microstructural Injury in Patients With Acute Single Subcortical Infarction: A Preliminary Tract-Based Spatial Statistics With Atlas-Based Analysis [0.03%]
单皮质下梗死患者的白质微结构损伤：基于图谱的TBSS初步分析
Zilong Zhu,Tianyi Shen,Junfeng Xiong et al.
Zilong Zhu et al.
Background: Acute single subcortical infarction (ASSI) is a prevalent cerebrovascular disorder in clinical practice. Although progress has been made in understanding its central mechanisms, the patterns of white matter (W...
Resting-State Coactivation Patterns of Language Reorganization in Brain Tumors [0.03%]
脑肿瘤中语言重组的静息态协同激活模式
Antonio Napolitano,Leonardo Spitoni,Mehrnaz Jenabi et al.
Antonio Napolitano et al.
We investigated the temporal dynamics of resting-state brain activity associated with language reorganization in patients with left-hemisphere brain tumors using coactivation pattern (CAP) analysis of functional MRI. This retrospective stud...
Selective Synaptic Remodeling in Rat Auditory and Visual Cortices Following Noise-Induced Permanent Hearing Loss in Adulthood [0.03%]
成人永久性听力损失后 rat 辅听皮层和视觉皮层的选择性突触重塑
Miao Zhao,Yanjie Bai,Yaxin Yang et al.
Miao Zhao et al.
In adults with acquired hearing loss, cortical reorganization and cross-modal plasticity critically influence the timing and outcomes of cochlear implantation. This study examined the effects of 2 weeks of bilateral auditory deprivation-ind...
A Life Without Olfactory Function Has Limited Effects on Cerebral White Matter Morphology [0.03%]
嗅觉缺失对大脑白质形态的影响有限
Anja L Winter,Moa Peter,Evelina Thunell et al.
Anja L Winter et al.
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent morph...
Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders [0.03%]
metab型谷氨酸受体依赖性突触可塑性在年龄相关神经退行性疾病中的作用
Shaik Basha,Aradhika Vijeev,Spandana S Nadig et al.
Shaik Basha et al.
Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age-rela...
Electroacupuncture Relieves Neuropathic Pain by Suppressing ACC Pyramidal Activity via mGluR5 Inhibition in CCI Mice [0.03%]
电针通过抑制mGluR5诱导的伏膈核锥体神经元活性治疗炎性神经病理性疼痛
Xiuxiu Zhuang,Ledan Huang,Fubei Nan et al.
Xiuxiu Zhuang et al.
Background: Electroacupuncture (EA) is widely used for analgesia, but its central mechanisms remain unclear. We investigated whether EA alleviates neuropathic pain by suppressing metabotropic glutamate receptor 5 (mGluR5)...