Rosiglitazone affects nitric oxide synthases and improves renal outcome in a rat model of severe ischemia/reperfusion injury [0.03%]
罗格列酮影响一氧化氮合酶并改善缺血/再灌注损伤严重大鼠模型的肾脏预后
Boris Betz,Reinhard Schneider,Tobias Kress et al.
Boris Betz et al.
Background. Nitric oxide (NO)-signal transduction plays an important role in renal ischemia/reperfusion (I/R) injury. NO produced by endothelial NO-synthase (eNOS) has protective functions whereas NO from inducible NO-synthase (iNOS) induce...
PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways [0.03%]
过氧化物酶体增殖激活受体与丝氨酸酶调节：氧化应激和炎症通路的调控
Jordi Camps,Anabel García-Heredia,Anna Rull et al.
Jordi Camps et al.
The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting a...
Peroxisome Proliferator-Activator Receptor γ: A Link between Macrophage CD36 and Inflammation in Malaria Infection [0.03%]
过氧化物酶体增殖激活受体γ连接疟疾感染中的巨噬细胞CD36和炎症反应
Yi Ren
Yi Ren
Severe malaria infection caused by Plasmodium falciparum is a global life-threatening disease and a leading cause of death worldwide. Intensive investigations have demonstrated that macrophages play crucial roles in control of inflammatory ...
Rosiglitazone and pioglitazone alter aromatase kinetic properties in human granulosa cells [0.03%]
罗格列酮和吡格列酮可改变人颗粒细胞芳香化酶动力学性质
Takako Araki,Miroslava Varadinova,Michael Goldman et al.
Takako Araki et al.
We have previously reported that, in human granulosa cells, thiazolidinediones rosiglitazone and pioglitazone inhibit estrogen synthesis by interfering with androgen binding to aromatase, without an effect on aromatase mRNA or protein expre...
William M Wood,Vibha Sharma,Kevin T Bauerle et al.
William M Wood et al.
Undifferentiated (anaplastic) thyroid cancer (ATC) is one of the most aggressive human malignancies and no effective therapy is currently available. We show here that PPARγ levels are elevated in cells derived from ATC. Depletion of PPARγ...
Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo [0.03%]
核受体RXR配体参与PPARγ激动剂体内抗炎作用的机制研究
Atsuki Yamamoto,Hiroki Kakuta,Hiroyuki Miyachi et al.
Atsuki Yamamoto et al.
Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs). It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice. Therefo...
PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5'-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells [0.03%]
过氧化物酶体增殖活化受体α激动剂非诺贝特通过增加人的血管内皮细胞中鸟苷三磷酸环水解酶-i的表达上调 tetrahydrobiopterin水平
Jinbo Liu,Changlin Lu,Fuwang Li et al.
Jinbo Liu et al.
Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide (NO) synthase. Guanosine 5'-triphosphate cyclohydrolase-I (GTPCH-I) is a key limiting enzyme for BH4 synthesis. In the present in vitro study, we investigated w...
Peroxisome Proliferator-Activated Receptor-α Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension [0.03%]
激活过氧化物酶体增殖活化受体-α降低DOCA盐高血压急性模型的平均动脉压、血浆白细胞介素-6和COX-2,同时增加肾CYP4A表达
Dexter L Lee,Justin L Wilson,Rong Duan et al.
Dexter L Lee et al.
Peroxisome proliferator-activated receptor-alpha (PPAR-α) activation by fenofibrate reduces blood pressure and sodium retention during DOCA-salt hypertension. PPAR-α activation reduces the expression of inflammatory cytokines, such as int...
Skeletal effects of the saturated 3-thia Fatty Acid tetradecylthioacetic Acid in rats [0.03%]
十三硫代乙酸盐对大鼠骨骼的影响
Astrid Kamilla Stunes,Irene Westbroek,Reidar Fossmark et al.
Astrid Kamilla Stunes et al.
This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or...
Rosiglitazone Restores Endothelial Dysfunction in a Rat Model of Metabolic Syndrome through PPARγ- and PPARδ-Dependent Phosphorylation of Akt and eNOS [0.03%]
罗格列酮通过PPARγ和PPARδ依赖的Akt和eNOS磷酸化恢复代谢综合征大鼠模型内皮功能障碍
Zhigang Zhao,Zhidan Luo,Peijian Wang et al.
Zhigang Zhao et al.
Vascular endothelial dysfunction has been demonstrated in metabolic syndrome (MS). Chronic administration of rosiglitazone ameliorates endothelial dysfunction through PPARγ-mediated metabolic improvements. Recently, studies suggested that ...