Judit Osz,Maxim V Pethoukhov,Serena Sirigu et al.
Judit Osz et al.
PPARγ is a key regulator of glucose homeostasis and insulin sensitization. PPARγ must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1α t...
Ko Fujimori
Ko Fujimori
Adipocytes and fat cells play critical roles in the regulation of energy homeostasis. Adipogenesis (adipocyte differentiation) is regulated via a complex process including coordinated changes in hormone sensitivity and gene expression. PPAR...
Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells [0.03%]
PPARγ和BMP2在间充质干细胞中的信号交叉对话
Ichiro Takada,Yoshiko Yogiashi,Shigeaki Kato
Ichiro Takada
Recent studies have revealed that PPARγ's transactivation function is regulated by extracellular signals. In particular, cytokines and Wnt family proteins suppress the ligand-inducible transactivation function of PPARγ and attenuate adipo...
PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma [0.03%]
过氧化物酶体增殖激活受体可能促肝细胞癌发病机制产生作用
Osamu Kimura,Yasuteru Kondo,Tooru Shimosegawa
Osamu Kimura
Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is know...
Effect of 2,4-thiazolidinedione on limousin cattle growth and on muscle and adipose tissue metabolism [0.03%]
2,4-噻唑烷二酮对利穆赞肉牛生长及肌肉和脂肪组织代谢的影响
M Arévalo-Turrubiarte,L González-Dávalos,A Yabuta et al.
M Arévalo-Turrubiarte et al.
The main adipogenic transcription factor PPARγ possesses high affinity to 2,4-TZD, a member of the Thiazolidinedione family of insulin-sensitizing compounds used as adipogenic agents. We evaluated 2,4-TZD's effect on bovine growth and PPAR...
Expression Pattern of Peroxisome Proliferator-Activated Receptors in Rat Hippocampus following Cerebral Ischemia and Reperfusion Injury [0.03%]
脑缺血再灌注损伤后大鼠海马区过氧化物酶体增殖激活受体表达模式分析
Hong Wang,Rong Jiang,Qin He et al.
Hong Wang et al.
The present study was designed to investigate the pattern of time-dependent expression of peroxisome proliferator-activated receptors (PPARα, β, and γ) after global cerebral ischemia and reperfusion (I/R) damage in the rat hippocampus. M...
Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity [0.03%]
核共抑制因子和PGC-1α的转录调节作用：对线粒体质量控制和胰岛素敏感性的影响
Zhengtang Qi,Shuzhe Ding
Zhengtang Qi
The peroxisome proliferator-activated receptors (PPARs) and estrogen-related receptor (ERRα) are ligand-activated nuclear receptors that coordinately regulate gene expression. Recent evidence suggests that nuclear corepressors, NCoR, RIP14...
Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity [0.03%]
人肥胖症患者非酒精性脂肪肝病相关过氧化物酶体增殖激活受体功能失调及其致病后果
Luis A Videla,Paulina Pettinelli
Luis A Videla
Nonalcoholic fatty liver disease in human obesity is characterized by the multifactorial nature of the underlying pathogenic mechanisms, which include misregulation of PPARs signaling. Liver PPAR-α downregulation with parallel PPAR-γ and ...
Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus [0.03%]
过氧化物酶体增殖激活受体γ通过抑制NF-κB向细胞核转位加重刀豆蛋白A诱导的肝损伤
Yuji Ogawa,Masato Yoneda,Wataru Tomeno et al.
Yuji Ogawa et al.
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to reduce inflammation and attenuate fibrosis in the liver. In this study, we investigated the effects of PPARγ on the liver injury induced by 20 mg/kg Concanavalin A...
Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases [0.03%]
营养补充剂调节PPAR-γ作为肥胖相关性疾病和炎症性疾病的辅助治疗手段
D Ortuño Sahagún,A L Márquez-Aguirre,S Quintero-Fabián et al.
D Ortuño Sahagún et al.
A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse...