The Interplay of PPARs with Parasites and Related Intracellular Pathogens [0.03%]
PPARs与寄生虫及相关的胞内病原菌的相互作用
Marion M Chan,Dunne Fong
Marion M Chan
Fenofibrate enhances the in vitro differentiation of foxp3(+) regulatory T cells in mice [0.03%]
菲诺贝特增强小鼠体外FoxP3+调节性T细胞的分化
Zhou Zhou,Ying Liang,Yanxiang Gao et al.
Zhou Zhou et al.
Foxp3(+) regulatory T cells (Tregs) play a critical role in maintaining immune self-tolerance. Reduced number and activity of Tregs are usually found in autoimmune and inflammatory diseases, and enhancing the differentiation of Tregs may be...
New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury [0.03%]
过氧化物酶体增殖活化受体在组织损伤后调节炎症反应中的作用的新见解
Miriam D Neher,Sebastian Weckbach,Markus S Huber-Lang et al.
Miriam D Neher et al.
Major trauma results in a strong inflammatory response in injured tissue. This posttraumatic hyperinflammation has been implied in the adverse events leading to a breakdown of host defense mechanisms and ultimately to delayed organ failure....
Simone Polvani,Mirko Tarocchi,Andrea Galli
Simone Polvani
Peroxisome-proliferator activator receptor γ (PPARγ) is a nuclear receptor of central importance in energy homeostasis and inflammation. Recent experimental pieces of evidence demonstrate that PPARγ is implicated in the oxidative stress ...
The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells [0.03%]
噻唑烷二酮类PPARγ激动剂调节人类前列腺癌细胞中PPARγ非依赖型、MEK依赖型Erk1/2磷酸化信号途径的研究
Adrienne Bolden,Lynikka Bernard,Danielle Jones et al.
Adrienne Bolden et al.
Thiazolidinediones (TZDs) dramatically reduce the growth of human prostate cancer cells in vitro and in vivo. To determine whether the antitumor effects of TZDs were due in part to changes in the MEK/Erk signaling pathway, we examined the r...
Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection [0.03%]
PPAR-γ介导的利什曼原虫感染中巨噬细胞极化的作用
Marion M Chan,Nagasuresh Adapala,Cui Chen
Marion M Chan
Infection is the outcome of a contest between a pathogen and its host. In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages. Leishmania species adapt strategies to make the infection chronic, k...
Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy [0.03%]
PPARs在克氏锥虫感染中的作用及其对查加斯病治疗的意义
Eugenia Hovsepian,Federico Penas,Gerardo A Mirkin et al.
Eugenia Hovsepian et al.
Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in d...
Altered peroxisome-proliferator activated receptors expression in human endometrial cancer [0.03%]
人子宫内膜癌中过氧化物酶体增殖激活受体表达异常
Paweł Knapp,Adrian Chabowski,Agnieszka Błachnio-Zabielska et al.
Paweł Knapp et al.
Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear hormone receptors acting as transcriptional factors, recently involved also in carcinogenesis. Present study was undertaken to evaluate the presence and subce...
The renoprotective actions of peroxisome proliferator-activated receptors agonists in diabetes [0.03%]
糖尿病中过氧化物酶体增殖活化受体激动剂的肾保护作用
M C Thomas,K A Jandeleit-Dahm,C Tikellis
M C Thomas
Pharmaceutical agonists of peroxisome proliferator-activated receptors (PPARs) are widely used in the management of type 2 diabetes, chiefly as lipid-lowering agents and oral hypoglycaemic agents. Although most of the focus has been placed ...
The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course [0.03%]
PPARγ基因变异对炎症性肠病易感性和病程的影响
Jessica Mwinyi,Christa Grete-Wenger,Jyrki J Eloranta et al.
Jessica Mwinyi et al.
PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting...