The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury [0.03%]
PPARs在肝脏缺血再灌注损伤中作用的当前认识
M Elias-Miró,M B Jiménez-Castro,M Mendes-Braz et al.
M Elias-Miró et al.
Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulat...
Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation [0.03%]
从控制脂肪生成和对抗炎症入手，使用奎尼宁防治高脂饮食引起的肥胖症
Sung A Jung,Miseon Choi,Sohee Kim et al.
Sung A Jung et al.
Cinchonine (C(19)H(22)N(2)O) is a natural compound of Cinchona bark. Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied. The main objective of this stud...
Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease [0.03%]
PPAR-γ激动剂治疗的肾脏全基因表达谱分析一个新的致死型常染色体隐性遗传多囊肾病大鼠模型中
Daisuke Yoshihara,Masanori Kugita,Tamio Yamaguchi et al.
Daisuke Yoshihara et al.
Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreas...
Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency [0.03%]
trifunctional蛋白缺陷导致成纤维细胞脂酸堆积及PPARα活化
Masato Wakabayashi,Yuji Kamijo,Takero Nakajima et al.
Masato Wakabayashi et al.
To examine fatty acid accumulation and its toxic effects in cells, we analyzed skin fibroblasts from six patients with mitochondrial trifunctional protein deficiency, who had abnormalities in the second through fourth reactions in fatty aci...
PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials [0.03%]
PPARs：干扰瓦尔堡效应与临床抗癌试验
Joseph Vamecq,Jean-Marie Colet,Jean Jacques Vanden Eynde et al.
Joseph Vamecq et al.
The metabolic/cell signaling basis of Warburg's effect ("aerobic glycolysis") and the general metabolic phenotype adopted by cancer cells are first reviewed. Several bypasses are adopted to provide a panoramic integrated view of tumoral met...
Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice [0.03%]
PPARα激活剂诱导小鼠肝中硫酸肝苷脂转移酶的表达
Takefumi Kimura,Takero Nakajima,Yuji Kamijo et al.
Takefumi Kimura et al.
Sulfatides are one of the major sphingoglycolipids in mammalian serum and are synthesized and secreted mainly from the liver as a component of lipoproteins. Recent studies revealed a protective role for serum sulfatides against arterioscler...
AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells [0.03%]
JNK抑制剂AS601245和氯芬酸在诱导CaCo-2结肠癌细胞反应及影响基因表达模式方面具有协同作用
Angelo Cerbone,Cristina Toaldo,Stefania Pizzimenti et al.
Angelo Cerbone et al.
PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARα transcriptional activity can be negatively regulated by JNK, the...
PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds [0.03%]
核受体PPARα通过诱导解毒基因表达介导植物源不良化合物的代谢排毒作用
Bunichiro Ashibe,Yu Nakajima,Yuka Fukui et al.
Bunichiro Ashibe et al.
Plants contain potentially toxic compounds for animals and animals have developed physiological strategies to detoxify the ingested toxins during evolution. Feeding mice with various plant seeds and grains showed unexpected result that only...
Pioglitazone attenuates vascular fibrosis in spontaneously hypertensive rats [0.03%]
吡格列酮减轻自发性高血压大鼠血管纤维化
Dengfeng Gao,Ning Ning,Guanghua Hao et al.
Dengfeng Gao et al.
Objective. We sought to investigate whether the peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand pioglitazone can attenuate vascular fibrosis in spontaneously hypertensive rats (SHRs) and explore the possible molecular mechani...
Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo [0.03%]
人PPARδ及hPPARδ显性阴性变异体的条件表达研究
Larry G Higgins,Wojciech G Garbacz,Mattias C U Gustafsson et al.
Larry G Higgins et al.
The nuclear receptor, NR1C2 or peroxisome proliferator-activated receptor (PPAR)-δ, is ubiquitously expressed and important for placental development, fatty acid metabolism, wound healing, inflammation, and tumour development. PPARδ has b...