Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver [0.03%]
增塑剂可能较弱地激活人的肝过氧化物酶体增殖活化受体α但能激活肝脏的构型雄甾烷受体
Yuki Ito,Toshiki Nakamura,Yukie Yanagiba et al.
Yuki Ito et al.
Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as plasticizers. Their metabolites activate peroxisome proliferator-activated receptor (PPAR) α, which may be related to their toxicities...
Zhou Zhou,Weiliang Sun,Ying Liang et al.
Zhou Zhou et al.
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activi...
Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases [0.03%]
PPARγ激动剂在肺疾病中的非PPARγ依赖性作用的初步探索
Ajit A Kulkarni,Collynn F Woeller,Thomas H Thatcher et al.
Ajit A Kulkarni et al.
Peroxisome proliferator activated receptor (PPAR)-γ is a nuclear hormone receptor that is activated by multiple agonists including thiazolidinediones, prostaglandins, and synthetic oleanolic acids. Many PPARγ ligands are under investigati...
PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases [0.03%]
PPARγ作为治疗慢性气道炎症性疾病气道黏液高分泌的潜在靶点
Yongchun Shen,Lei Chen,Tao Wang et al.
Yongchun Shen et al.
Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease. AMH contributes to the pathogenesis of chron...
Angélica Amorim Amato,Francisco de Assis Rocha Neves
Angélica Amorim Amato
The incidence of type 2 (T2D) diabetes and other chronic conditions associated with insulin resistance is increasing at an alarming rate, underscoring the need for effective and safe therapeutic strategies. Peroxisome-proliferator-activated...
Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1α-Mediated Fatty Acid Oxidation [0.03%]
柑橘黄酮通过激活肝PGC1α介导的脂肪酸氧化来防御代谢紊乱、肥胖和动脉粥样硬化
Erin E Mulvihill,Murray W Huff
Erin E Mulvihill
Studies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce ath...
Peroxisome proliferator-activated receptorα agonists differentially regulate inhibitor of DNA binding expression in rodents and human cells [0.03%]
过氧化物酶体增殖激活受体α激动剂对啮齿类和人类细胞中DNA结合蛋白表达的差异调节作用研究
María Del Carmen González,J Christopher Corton,Nuria Acero et al.
María Del Carmen González et al.
Inhibitor of DNA binding (Id2) is a helix-loop-helix (HLH) transcription factor that participates in cell differentiation and proliferation. Id2 has been linked to the development of cardiovascular diseases since thiazolidinediones, antidia...
The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists [0.03%]
PPARγ在配体诱导的转录调控中的作用研究进展及其机制分析
Tamotsu Tsukahara
Tamotsu Tsukahara
In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human dise...
Yoko Tabe,Marina Konopleva,Michael Andreeff et al.
Yoko Tabe et al.
Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions. PPARs form heterodimers ...
PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling [0.03%]
激活PPARα通过抑制肾小球NF-κB信号转导来抵抗Anti-Thy1诱导的肾炎
Koji Hashimoto,Yuji Kamijo,Takero Nakajima et al.
Koji Hashimoto et al.
The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulo...