The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice [0.03%]
硝化脂肪酸10-硝基油酸减轻脂多糖诱导的小鼠急性肺损伤的严重性
Aravind T Reddy,Sowmya P Lakshmi,Raju C Reddy
Aravind T Reddy
Acute lung injury (ALI) is an inflammatory condition culminating in respiratory failure. There is currently no effective pharmacological treatment. Nitrated fatty acids (NFAs) have been shown to exert anti-inflammatory effects. We therefore...
Anthony J Apostoli,Christopher J B Nicol
Anthony J Apostoli
ATP-dependent binding cassette (ABC) transporters are a family of transmembrane proteins that pump a variety of hydrophobic compounds across cellular and subcellular barriers and are implicated in human diseases such as cancer and atheroscl...
Correlations among PPARγ, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer [0.03%]
PPARγ、DNMT1和DNMT3B的表达量与胰腺癌的相关性研究
Valerio Pazienza,Francesca Tavano,Giorgia Benegiamo et al.
Valerio Pazienza et al.
Emerging evidence indicates that peroxisome proliferator-activated receptor γ (PPARγ) and DNA methyltransferases (DNMTs) play a role in carcinogenesis. In this study we aimed to evaluate the expression of PPARγ, DNMT1, and DNMT3B and the...
PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing [0.03%]
核受体PPARγ在结核分枝杆菌感染中的表达及功能研究：脂代谢、免疫与杀菌作用的相互关联
Patricia E Almeida,Alan Brito Carneiro,Adriana R Silva et al.
Patricia E Almeida et al.
Tuberculosis continues to be a global health threat, with drug resistance and HIV coinfection presenting challenges for its control. Mycobacterium tuberculosis, the etiological agent of tuberculosis, is a highly adapted pathogen that has ev...
PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis [0.03%]
PPARG表观遗传失调及其在结直肠肿瘤发生中的作用
Lina Sabatino,Alessandra Fucci,Massimo Pancione et al.
Lina Sabatino et al.
Peroxisome proliferator-activated receptor gamma (PPARγ) plays critical roles in lipid storage, glucose metabolism, energy homeostasis, adipocyte differentiation, inflammation, and cancer. Its function in colon carcinogenesis has largely b...
Peroxisome Proliferator Activated Receptor-α Agonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice [0.03%]
过氧化物酶体增殖活化受体激动剂减缓高血压的发展，减轻血管紧张素Ⅱ诱导的高血压小鼠血浆中白细胞介素-6水平和肾脏炎症标志物
Justin L Wilson,Rong Duan,Ahmed El-Marakby et al.
Justin L Wilson et al.
The anti-inflammatory properties of PPAR-α plays an important role in attenuating hypertension. The current study determines the anti-hypertensive and anti-inflammatory role of PPAR-α agonist during a slow-pressor dose of Ang II (400 ng/k...
Prenatal rosiglitazone administration to neonatal rat pups does not alter the adult metabolic phenotype [0.03%]
孕鼠服用罗格列酮不影响子代大鼠成年期代谢表型
Hernan Sierra,Reiko Sakurai,W N Paul Lee et al.
Hernan Sierra et al.
Prenatally administered rosiglitazone (RGZ) is effective in enhancing lung maturity; however, its long-term safety remains unknown. This study aimed to determine the effects of prenatally administered RGZ on the metabolic phenotype of adult...
Meera Penumetcha,Nalini Santanam
Meera Penumetcha
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that respond to several exogenous and endogenous ligands by modulating genes related to lipid, glucose, and insulin homeostasis. PPARγ, expressed in...
PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation [0.03%]
激活PPARδ通过增强脂肪酸氧化缓解棕榈酸诱导的胰岛β细胞内质网应激作用机制研究
Mingming Cao,Yuzhen Tong,Qingguo Lv et al.
Mingming Cao et al.
One of the key factors responsible for the development of type 2 diabetes is the loss of functional pancreatic β cells. This occurs due to a chronic exposure to a high fatty acid environment. ER stress is caused by an accumulation of irrev...
PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung [0.03%]
PPARγ信号传导介导肺的进化、发育、稳态和修复
Virender K Rehan,John S Torday
Virender K Rehan
Epithelial-mesenchymal interactions mediated by soluble growth factors determine the evolution of vertebrate lung physiology, including development, homeostasis, and repair. The final common pathway for all of these positively adaptive prop...