Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity [0.03%]
染色质结构控制在脂肪细胞发生和肥胖中的作用：协同调节PPARγ表达及活性
Jérôme Eeckhoute,Frédérik Oger,Bart Staels et al.
Jérôme Eeckhoute et al.
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes. Its expression is induced during adipogenesis where it plays a key role in establishing the tr...
Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury [0.03%]
过氧化物酶体增殖活化受体α在血管损伤后单核细胞趋化蛋白-1表达和内膜增生中发挥作用
Yu Peng,Qiang Li,Lu Zhang et al.
Yu Peng et al.
Peroxisome proliferator-activated receptor α is a member of the nuclear receptor superfamily. It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro. In this study, we tested the hypothesis that PPARα would decr...
The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination [0.03%]
PPARγ配体化疗潜力的钥匙：正确的组合方法
Graham Skelhorne-Gross,Christopher J B Nicol
Graham Skelhorne-Gross
Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. In spite...
Gene P Ables
Gene P Ables
Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. Insulin...
Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines [0.03%]
PPARγ、DNMT1和DNMT3B在胰腺癌细胞系中表达的时间变化模式
Valerio Pazienza,Francesca Tavano,Massimo Francavilla et al.
Valerio Pazienza et al.
Carcinogenesis is related to the loss of homeostatic control of cellular processes regulated by transcriptional circuits and epigenetic mechanisms. Among these, the activities of peroxisome proliferator-activated receptors (PPARs) and DNA m...
PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy [0.03%]
过氧化物酶体增殖激活受体γ配体通过调节气道平滑肌的非收缩和收缩功能影响哮喘治疗：来自细胞和整体动物模型的新证据
Chantal Donovan,Xiahui Tan,Jane Elizabeth Bourke
Chantal Donovan
In asthma, the increase in airway smooth muscle (ASM) can contribute to inflammation, airway wall remodeling and airway hyperresponsiveness (AHR). Targetting peroxisome proliferator-activated receptor γ (PPARγ), a receptor upregulated in ...
Francesca Agriesti,Tiziana Tataranni,Vitalba Ruggieri et al.
Francesca Agriesti et al.
Hepatitis-C-virus-related infective diseases are worldwide spread pathologies affecting primarily liver. The infection is often asymptomatic, but when chronically persisting can lead to liver scarring and ultimately to cirrhosis, which is g...
The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils [0.03%]
PPAR激动剂对成熟和不成熟嗜酸性粒细胞迁移的影响
Steven G Smith,Haruki Imaoka,Neha Punia et al.
Steven G Smith et al.
PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis). To date, the effects of PPAR agonists on chemokinesis have not been examined. ...
The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis [0.03%]
PPARγ在幽门螺旋杆菌感染及胃癌发生发展中的作用研究进展
Jong-Min Lee,Sung Soo Kim,Young-Seok Cho
Jong-Min Lee
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogen...
Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword [0.03%]
PPARγ在肺癌进展中的抗肿瘤和促肿瘤作用：一把双刃剑
Howard Li,Mary C M Weiser-Evans,Raphael Nemenoff
Howard Li
Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiolog...