Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling [0.03%]
Rhein通过抑制PPARγ信号通路减少db/db小鼠脂肪重量及C57Bl/6小鼠饮食诱导的肥胖效应
Yu Zhang,Shengjie Fan,Na Hu et al.
Yu Zhang et al.
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine. However, the components of Rheum palmatum that play the antiobesity role are still uncertain. Here, we tested the weight-reducing ...
Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer [0.03%]
过氧化物酶体增殖激活受体gamma与泛素-蛋白酶体系统在胰腺癌中的调节作用研究
Athina Stravodimou,Gianluigi Mazzoccoli,Ioannis A Voutsadakis
Athina Stravodimou
Pancreatic cancer is one of the most lethal forms of human cancer. Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remai...
Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes [0.03%]
瘦素在生长板软骨细胞中拮抗过氧化物酶体增殖激活受体gamma信号转导的作用
Lai Wang,Yvonne Y Shao,R Tracy Ballock
Lai Wang
Leptin is an obesity-associated cytokine-like hormone encoded by the ob gene. Recent studies reveal that leptin promotes proliferation and differentiation of chondrocytes, suggesting a peripheral role of leptin in regulating growth plate fu...
Valerio Pazienza,Manlio Vinciguerra,Gianluigi Mazzoccoli
Valerio Pazienza
Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in can...
The role of peroxisome proliferator-activated receptors in colorectal cancer [0.03%]
过氧化物酶体增殖激活受体在结直肠癌中的作用
Joo-In Park,Jong-Young Kwak
Joo-In Park
Colorectal cancer is one of the most common cancers in the world. Dietary fat intake is a major risk factor for colorectal cancer. Some nuclear hormone receptors play an important role in regulating nutrient metabolism and energy homeostasi...
PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs [0.03%]
肝病和癌症中的PPARs：microRNA的表观遗传调控作用
Marion Peyrou,Pierluigi Ramadori,Lucie Bourgoin et al.
Marion Peyrou et al.
Peroxisome-proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that exert in the liver a transcriptional activity regulating a whole spectrum of physiological functions, including cholesterol and bile acid homeos...
PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists [0.03%]
过氧化物酶体增殖活化受体α非依赖性的血管平滑肌松弛效应及其机制研究
Neerupma Silswal,Nikhil K Parelkar,Michael J Wacker et al.
Neerupma Silswal et al.
We sought to determine direct vascular effects of peroxisome proliferator-activated receptor alpha (PPARα) agonists using isolated mouse aortas and middle cerebral arteries (MCAs). The PPARα agonists GW7647, WY14643, and gemfibrozil acute...
Vito Annese,Francesca Rogai,Alessia Settesoldi et al.
Vito Annese et al.
Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors. The colon is a major tissue which expresses PPARγ in epithel...
TGFβ1 Controls PPARγ Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts [0.03%]
TGFβ1通过Smad3信号通路在一定程度上控制PPARγ在小鼠肺成纤维细胞中的表达、转录潜能和活性
Allan Ramirez,Erin N Ballard,Jesse Roman
Allan Ramirez
Transforming growth factor β1 (TGFβ1) promotes fibrosis by, among other mechanisms, activating quiescent fibroblasts into myofibroblasts and increasing the expression of extracellular matrices. Recent work suggests that peroxisome prolife...
The role of peroxisome proliferator-activated receptors in the esophageal, gastric, and colorectal cancer [0.03%]
过氧化物酶体增殖激活受体在食管、胃和结直肠癌中的作用
Alessandra Fucci,Tommaso Colangelo,Carolina Votino et al.
Alessandra Fucci et al.
Tumors of the gastrointestinal tract are among the most frequent human malignancies and account for approximately 30% of cancer-related deaths worldwide. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription...