Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer [0.03%]
靶向PPARγ信号通路以预防和治疗前列腺癌
Sakshi Sikka,Luxi Chen,Gautam Sethi et al.
Sakshi Sikka et al.
The peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the hormone-activated nuclear receptor superfamily. PPARγ can be activated by a diverse group of agents, such as endogenous polyunsaturated fatty acids, 15-deoxy-...
Valerio Pazienza
Valerio Pazienza
Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury [0.03%]
PPARα的抗氧化应激和抗炎对温热肝缺血再灌注损伤的作用研究
Zhixin Gao,Yuan-Hai Li
Zhixin Gao
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating t...
Raju C Reddy,Virender K Rehan,Jesse Roman et al.
Raju C Reddy et al.
Regulation of Genes Involved in Carnitine Homeostasis by PPARα across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human) [0.03%]
PPARα调控不同物种(大鼠、小鼠、猪、牛、鸡和人)体内肉毒碱稳态相关基因的表达规律研究
Robert Ringseis,Gaiping Wen,Klaus Eder
Robert Ringseis
Recent studies in rodents convincingly demonstrated that PPARα is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both o...
In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist [0.03%]
一种新型胰岛素增敏剂齐拉西酮的体内外特征研究
B K He,Z Q Ning,Z B Li et al.
B K He et al.
Solid rationales are still present for the identification of synthetic ligands to simultaneously target multiple PPAR subtypes for the treatment of T2DM. The purpose of this study was to characterize the in vitro and in vivo differential ef...
Yuji Kamijo,Christopher J Nicol,Stefan E H Alexson
Yuji Kamijo
Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism [0.03%]
TWIST1通过不同的机制调节PGC-1α和NT-PGC-1α的转录活性以影响棕色脂肪代谢
Hee-Jin Jun,Thomas W Gettys,Ji Suk Chang
Hee-Jin Jun
Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PP...
Effect of pioglitazone on the fructose-induced abdominal adipose tissue dysfunction [0.03%]
吡格列酮对果糖致腹脂组织功能障碍的影响
Ana Alzamendi,Andrés Giovambattista,María E García et al.
Ana Alzamendi et al.
Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial di...
Modulation of Preactivation of PPAR-β on Memory and Learning Dysfunction and Inflammatory Response in the Hippocampus in Rats Exposed to Global Cerebral Ischemia/Reperfusion [0.03%]
PPAR-β预激活对全脑缺血再灌注损伤大鼠海马炎症反应及学习记忆障碍的影响
Ge Kuang,Qin He,Yunmei Zhang et al.
Ge Kuang et al.
The aim of this study is to investigate the neuroprotective effects and relevant mechanism of GW0742, an agonist of PPAR-β, after global cerebral ischemia-reperfusion injury (GCIRI) in rats. The rats showed memory and cognitive impairment ...