Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes [0.03%]
PPARγ激动剂在血管、骨髓和眼中的造血系统恶性肿瘤中的抗肿瘤作用
P J Simpson-Haidaris,S J Pollock,S Ramon et al.
P J Simpson-Haidaris et al.
The use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of co...
Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity [0.03%]
PPARγ与胰岛素信号的相互作用及对胰岛素敏感性的影响
Anna Leonardini,Luigi Laviola,Sebastio Perrini et al.
Anna Leonardini et al.
PPARgamma activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARgamma action on...
Eric R Wagner,Bai-Cheng He,Liang Chen et al.
Eric R Wagner et al.
Osteosarcoma (OS) is the most common nonhematologic malignancy of bone in children and adults. Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability,...
Bonnie L Blazer-Yost
Bonnie L Blazer-Yost
Peroxisome proliferator activated receptor gamma (PPARgamma) agonists are widely used in the treatment of type 2 diabetes. Side effects of drug treatment include both fluid retention and a lowering of blood pressure. Data from animal and hu...
Lap Shu Alan Chan,Richard A Wells
Lap Shu Alan Chan
The PPARs are integral parts of the RXR-dependent signaling networks. Many other nuclear receptor subfamily 1 members also require RXR as their obligatory heterodimerization partner and they are often co-expressed in any given tissue. There...
Christine Linard,Maâmar Souidi
Christine Linard
The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. Th...
Regulation of Translational Efficiency by Disparate 5' UTRs of PPARgamma Splice Variants [0.03%]
PPARγ剪接变异体不同5'-UTR对翻译效率的调控作用
Shawn McClelland,Roopali Shrivastava,Jheem D Medh
Shawn McClelland
The PPAR-gamma gene encodes for at least 7 unique transcripts due to alternative splicing of five exons in the 5'-untranslated region (UTR). The translated region is encoded by exons 1-6, which are identical in all isoforms. This study inve...
Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease [0.03%]
过氧化物酶体增殖激活受体γ多态性与冠心病关系的研究进展
Jean Dallongeville,Carlos Iribarren,Jean Ferrières et al.
Jean Dallongeville et al.
Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPA...
Genetic Variation of PPARs [0.03%]
PPARs的遗传变异
Marie-Claude Vohl,Mostafa Badr,Stefan Wieczorek
Marie-Claude Vohl
Fasting Upregulates PPARalpha Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARalpha Dependent Manner [0.03%]
禁食通过PPARα依赖性方式上调脑内PPARα靶基因并影响垂体激素的表达
Bettina König,Christine Rauer,Susann Rosenbaum et al.
Bettina König et al.
PPARalpha is a lipid-activable transcription factor that mediates the adaptive response to fasting. Recent data indicate an important role of brain PPARalpha in physiological functions. However, it has not yet been shown whether PPARalpha i...