Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors [0.03%]
过氧化物酶体增殖激活受体对ENaC介导的钠重吸收的调节作用
Tengis S Pavlov,John D Imig,Alexander Staruschenko
Tengis S Pavlov
Peroxisome proliferator-activated receptors (PPARs) are members of a steroid hormone receptor superfamily that responds to changes in lipid and glucose homeostasis. Peroxisomal proliferator-activated receptor subtype gamma (PPARgamma) has r...
Tamás Roszer,Mercedes Ricote
Tamás Roszer
Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPARalpha and PPARgamma modul...
Is there a biological basis for treatment of fibrodysplasia ossificans progressiva with rosiglitazone? Potential benefits and undesired effects [0.03%]
罗格列酮治疗进行性肌肉骨骼纤维发育不良的生物学基础及其利弊效应分析
Renata Bocciardi,Roberto Ravazzolo
Renata Bocciardi
Thiazolidinediones (TZDs), among which Rosiglitazone, are known agonists of the peroxisome-proliferator-activated receptor gamma (PPARgamma) commonly used for treatment of hyperglycemia. A recently published article describing a case report...
The peroxisome proliferator-activated receptor gamma system regulates ultraviolet B-induced prostaglandin e(2) production in human epidermal keratinocytes [0.03%]
过氧化物酶体增殖激活受体γ系统调控紫外线B诱导的人表皮角质细胞前列腺素E₂的产生
Raymond L Konger,Kellie Clay Martel,Danielle Jernigan et al.
Raymond L Konger et al.
Studies using PPARgamma agonists in mouse skin have suggested that peroxisome proliferator-activated receptor gamma (PPARgamma) is irrelevant to cutaneous photobiology. However, in several epithelial cell lines, ultraviolet B (UVB) has been...
Kinetic assessment and therapeutic modulation of metabolic and inflammatory profiles in mice on a high-fat and cholesterol diet [0.03%]
高脂高胆固醇饮食小鼠的代谢及炎症特征的动态评估及其调控研究
Laura W Engstrom,Loretta Bober,Shu-Cheng Chen et al.
Laura W Engstrom et al.
The kinetics of metabolic and inflammatory parameters associated with obesity were evaluated in a murine diet-induced obesity (DIO) model using a diet high in fat and cholesterol. Cellular infiltration and mediator production were assessed ...
James P Hardwick,John Y L Chiang
James P Hardwick
PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors [0.03%]
人类神经上皮肿瘤中的过氧化物酶体增殖激活受体（PPAR）：作为最常见的人类神经上皮瘤的抗癌疗法的PPAR配体
Elisabetta Benedetti,Renato Galzio,Barbara D&#x;Angelo et al.
Elisabetta Benedetti et al.
Neuroepithelial tumors represent a heterogeneous class of human tumors including benignant and malignant tumors. The incidence of central nervous system neoplasms ranges from 3.8 to 5.1 cases per 100,000 in the population. Among malignant n...
A Dominant-Negative PPARgamma Mutant Promotes Cell Cycle Progression and Cell Growth in Vascular Smooth Muscle Cells [0.03%]
一个显性的负PPARγ突变体在血管平滑肌细胞中促进细胞周期进程和细胞增殖
Joey Z Liu,Christopher J Lyon,Willa A Hsueh et al.
Joey Z Liu et al.
PPARgamma ligands have been shown to have antiproliferative effects on many cell types. We herein report that a synthetic dominant-negative (DN) PPARgamma mutant functions like a growth factor to promote cell cycle progression and cell prol...
PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease [0.03%]
过氧化物酶体增殖激活受体/视黄醇X受体调节脂肪酸代谢及ω-羟化酶(CYP4)同工酶：对防治脂肪肝脂毒性的影响
James P Hardwick,Douglas Osei-Hyiaman,Homer Wiland et al.
James P Hardwick et al.
Fatty liver disease is a common lipid metabolism disorder influenced by the combination of individual genetic makeup, drug exposure, and life-style choices that are frequently associated with metabolic syndrome, which encompasses obesity, d...
Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans [0.03%]
肿瘤抑制基因候选者5的分子特征：由PPARγ调节及在瘦人和肥胖者中鉴定TUSC5编码变异体
Trina A Knotts,Hyun Woo Lee,Jae Bum Kim et al.
Trina A Knotts et al.
Tumor suppressor candidate 5 (TUSC5) is a gene expressed abundantly in white adipose tissue (WAT), brown adipose tissue (BAT), and peripheral afferent neurons. Strong adipocyte expression and increased expression following peroxisome prolif...