The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease [0.03%]
Peroxisome增生激活受体beta/delta在代谢性炎症疾病中的作用研究进展
Teresa Coll,Emma Barroso,David Alvarez-Guardia et al.
Teresa Coll et al.
The pathophysiology underlying several metabolic diseases, such as obesity, type 2 diabetes mellitus, and atherosclerosis, involves a state of chronic low-level inflammation. Evidence is now emerging that the nuclear receptor Peroxisome Pro...
Ichiro Takada,Alexander P Kouzmenko,Shigeaki Kato
Ichiro Takada
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-gamma acts as a key regulator of the adipogenesis. S...
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways [0.03%]
过氧化物酶体增殖激活受体、心血管代谢和功能：近平衡或远平衡途径
Yves Lecarpentier,Victor Claes,Jean-Louis Hébert
Yves Lecarpentier
Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have var...
Peroxisome proliferator-activated receptors alpha, Beta, and gamma mRNA and protein expression in human fetal tissues [0.03%]
人胎盘和胎儿组织中PPARα、PPARβ/δ及PPARγ的表达分布研究
Barbara D Abbott,Carmen R Wood,Andrew M Watkins et al.
Barbara D Abbott et al.
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants. Almost nothing is known about expression of PPARs during human...
Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARalpha [0.03%]
PPARα在肠道菌群诱导的先天免疫介导结肠炎发病和进展中的作用及其机制研究
Bianca Knoch,Matthew P G Barnett,Janine Cooney et al.
Bianca Knoch et al.
The interleukin-10 gene-deficient (Il10(-/-)) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10(-/-) model. The ai...
Effects of Endogenous PPAR Agonist Nitro-Oleic Acid on Metabolic Syndrome in Obese Zucker Rats [0.03%]
内源性PPAR激动剂硝基油酸对肥胖Zucker大鼠代谢综合征的影响
Haiping Wang,Haiying Liu,Zhanjun Jia et al.
Haiping Wang et al.
Nitroalkene derivatives of nitro-oleic acid (OA-NO(2)) are endogenous lipid products with novel signaling properties, particularly the activation of PPARs. The goal of this proposal was to examine the therapeutic potential of this OA-NO(2) ...
PPAR-alpha Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice [0.03%]
动销素调节verbascoside抗炎活性的作用机制研究
Emanuela Esposito,Emanuela Mazzon,Irene Paterniti et al.
Emanuela Esposito et al.
The previous results suggest that peroxisome proliferator-activated receptor-alpha (PPAR)-alpha, an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation. There is persuasive epidemiological an...
Michael E C Robbins,Christine Linard,Dipak Panigrahy
Michael E C Robbins
Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism [0.03%]
来源于草本及食用植物的多种萜类化合物可作为PPAR调节剂并调控糖脂代谢
Tsuyoshi Goto,Nobuyuki Takahashi,Shizuka Hirai et al.
Tsuyoshi Goto et al.
Several herbal plants improve medical conditions. Such plants contain many bioactive phytochemicals. Terpenoids (also called "isoprenoids") constitute one of the largest families of natural products accounting for more than 40,000 individua...
Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role? [0.03%]
糖尿病中的同型半胱氨酸与高血压：PPARγ是否具有调节作用？
Utpal Sen,Suresh C Tyagi
Utpal Sen
Dysfunction of macro- and microvessels is a major cause of morbidity and mortality in patients with cardio-renovascular diseases such as atherosclerosis, hypertension, and diabetes. Renal failure and impairment of renal function due to vaso...