Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3 [0.03%]
过氧化物酶体增殖激活受体通过14-3-3蛋白对抗细胞凋亡作用
Kenneth K Wu
Kenneth K Wu
Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports in...
Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation [0.03%]
过氧化物酶体增殖激活受体亚型特异性转录激活作用的分子机制及其基因组特征
Anne Bugge,Susanne Mandrup
Anne Bugge
The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very differe...
Regulation of PPARγ Coactivator-1α Function and Expression in Muscle: Effect of Exercise [0.03%]
调节肌肉中PPARγ辅活化物-1α的功能和表达：运动的影响
Giulia Uguccioni,Donna D&#x;souza,David A Hood
Giulia Uguccioni
PPARγ coactivator-1α (PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscl...
Lena Burri,G Hege Thoresen,Rolf K Berge
Lena Burri
PPARα is one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with P...
Involvement of Fatty Acid Binding Protein 5 and PPARβ/δ in Prostate Cancer Cell Growth [0.03%]
脂肪酸结合蛋白5和PPARβ/δ在前列腺癌细胞增殖中的作用
Elwin Morgan,Padmamalini Kannan-Thulasiraman,Noa Noy
Elwin Morgan
Fatty acid binding protein 5 (FABP5) delivers ligands from the cytosol directly to the nuclear receptor PPARβ/δ and thus facilitates the ligation and enhances the transcriptional activity of the receptor. We show here that expression leve...
Hiroshi Hasegawa,Hiroyuki Takano,Issei Komuro
Hiroshi Hasegawa
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression...
Woo Hyung Lee,Sang Geon Kim
Woo Hyung Lee
Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARalpha, PPARbeta/delta, and PPARgamma, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR s...
Navin Viswakarma,Yuzhi Jia,Liang Bai et al.
Navin Viswakarma et al.
Peroxisome proliferator-activated receptor (PPAR)alpha, beta (also known as delta), and gamma function as sensors for fatty acids and fatty acid derivatives and control important metabolic pathways involved in the maintenance of energy bala...
PPARs: Nuclear Receptors Controlled by, and Controlling, Nutrient Handling through Nuclear and Cytosolic Signaling [0.03%]
核受体PPAR通过细胞核和细胞质信号调控营养物质的吸收与代谢
Maria Moreno,Assunta Lombardi,Elena Silvestri et al.
Maria Moreno et al.
Peroxisome proliferator-activated receptors (PPARs), which are known to regulate lipid homeostasis, are tightly controlled by nutrient availability, and they control nutrient handling. In this paper, we focus on how nutrients control the ex...
PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study [0.03%]
PPARγ配体作为结直肠癌化学预防候选药物的探索性研究
Hirokazu Takahashi,Kunihiro Hosono,Takashi Uchiyama et al.
Hirokazu Takahashi et al.
Activating synthetic ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), such as pioglitazone, are commonly used to treat persons with diabetes mellitus with improvement of insulin resistance. Several reports have clea...