Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice [0.03%]
吡格列酮对糖尿病小鼠肝、腓肠肌和脂肪组织基本代谢途径的转录组学和代谢组学影响的协调作用研究
Sabrina Le Bouter,Marianne Rodriguez,Nolwen Guigal-Stephan et al.
Sabrina Le Bouter et al.
Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the ca...
Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects [0.03%]
基因表达谱分析揭示全氟辛烷磺酸的PPARα非依赖效应
Mitchell B Rosen,Judith R Schmid,J Christopher Corton et al.
Mitchell B Rosen et al.
Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife. Although blood levels of PFOS have begun to decline, health concerns remain because of ...
Maryam Rakhshandehroo,Bianca Knoch,Michael Müller et al.
Maryam Rakhshandehroo et al.
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeosta...
Annelies Peeters,Myriam Baes
Annelies Peeters
Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPARα is the master regulator of lipid metabolism during fasti...
Developmental effects of perfluorononanoic Acid in the mouse are dependent on peroxisome proliferator-activated receptor-alpha [0.03%]
过氧化物酶体增殖激活受体α决定全氟辛酸对小鼠的发育毒性作用
Cynthia J Wolf,Robert D Zehr,Judy E Schmid et al.
Cynthia J Wolf et al.
Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids found in the environment and in tissues of humans and wildlife. Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human...
PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex [0.03%]
来自PPARα相互作用共激活因子复合物的核受体共激活子PRIC295
Sean R Pyper,Navin Viswakarma,Yuzhi Jia et al.
Sean R Pyper et al.
The peroxisome proliferator-activated receptor-α (PPARα) plays a key role in lipid metabolism and energy combustion. Chronic activation of PPARα in rodents leads to the development of hepatocellular carcinomas. The ability of PPARα to i...
Yuji Naito,Tomohisa Takagi,Toshikazu Yoshikawa
Yuji Naito
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained ...
PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease [0.03%]
核受体在代谢稳态及病理生理中的作用
Purin Charoensuksai,Wei Xu
Purin Charoensuksai
The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. The circadian system is comprised of a master clock located in central nervous sy...
Michung Yoon
Michung Yoon
Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα r...
PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues [0.03%]
PPARG：基因表达调控及下一代测序技术解决未决问题
Valerio Costa,Maria Assunta Gallo,Francesca Letizia et al.
Valerio Costa et al.
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes. It is of particular...