Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α [0.03%]
过氧化物酶体增殖激活受体α活化剂对蛋白质维持基因表达的调节作用
Hongzu Ren,Beena Vallanat,Holly M Brown-Borg et al.
Hongzu Ren et al.
The nuclear receptor peroxisome proliferator-activated receptor α (PPARα) is activated by a large number of xenobiotic and hypolipidemic compounds called peroxisome proliferator chemicals (PPCs). One agonist of PPARα (WY-14,643) regulate...
Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation [0.03%]
激活过氧化物酶体增殖激活受体δ诱发胃癌转移
Claire B Pollock,Olga Rodriguez,Philip L Martin et al.
Claire B Pollock et al.
Peroxisome proliferator-activated receptorδ (PPARδ) regulates a multiplicity of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. One or more of these processes likely create risk facto...
WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis [0.03%]
WY-14643通过激活PPAR-α改善实验性牙周炎的炎症过程
Enrico Briguglio,Rosanna Di Paola,Irene Paterniti et al.
Enrico Briguglio et al.
We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone...
Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs [0.03%]
PPAR调节免疫反应和自身免疫性脑脊髓炎
Yuhong Yang,Amy E Lovett-Racke,Michael K Racke
Yuhong Yang
PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in regulating inflammation as well as lipid metabolism. The PPAR subfamily has been defined as PPARα, PPARβ/δ, and PPARγ, each with differe...
Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism [0.03%]
过氧化物酶体增殖活化受体-β/δ、-γ激动剂以及白藜芦醇调节低氧引起的肌肉氧化代谢激活因子变化
Timothy R H Regnault,Lin Zhao,Jacky S S Chiu et al.
Timothy R H Regnault et al.
PPAR-α, PPAR-β, and PPAR-γ, and RXR in conjunction with PGC-1α and SIRT1, activate oxidative metabolism genes determining insulin sensitivity. In utero, hypoxia is commonly observed in Intrauterine Growth Restriction (IUGR), and reduced...
Ching-Feng Cheng,Hsi-Hsien Chen,Heng Lin
Ching-Feng Cheng
Peroxisome proliferator-activated receptor (PPAR)-α, a member of a large nuclear receptor superfamily, plays a major role in the regulation of lipid metabolism. Recently, PPARα activation has been shown to confer additional benefits on en...
Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease [0.03%]
吡格列酮减轻PCK多囊肾病啮齿类模型的囊肿负荷
Bonnie L Blazer-Yost,Julie Haydon,Tracy Eggleston-Gulyas et al.
Bonnie L Blazer-Yost et al.
Polycystic kidney disease (PKD) is a genetic disorder characterized by growth of fluid-filled cysts predominately in kidney tubules and liver bile ducts. Currently, the clinical management of PKD is limited to cyst aspiration, surgical rese...
Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver [0.03%]
PPAR伽玛激动剂诱导的动物和人肝基因表达变化
Alexandra Rogue,Catherine Spire,Manuel Brun et al.
Alexandra Rogue et al.
Thiazolidinediones are a class of Peroxisome Proliferator Activated Receptor γ (PPARγ) agonists that reduce insulin resistance in type 2 diabetic patients. Although no detectable hepatic toxicity has been evidenced in animal studies durin...
Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes [0.03%]
激活PPARα、β/δ和γ抑制转化生长因子β1诱导的三维培养软骨细胞中的胶原蛋白产生并调节TIMP-1/MMP平衡
Paul-Emile Poleni,Stephanie Etienne,Emilie Velot et al.
Paul-Emile Poleni et al.
Background and Purpose. We investigated the potency of Peroxisome Proliferators-Activated Receptors (PPARs) α, β/δ, and γ agonists to modulate Transforming Growth Factor-β1 (TGF-β1-) induced collagen production or changes in Tissue In...
Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism [0.03%]
PPARα激动剂及常用调血脂药物苯扎贝特对肝毒性和脂代谢的影响
Michael L Cunningham,Bradley J Collins,Milton R Hejtmancik et al.
Michael L Cunningham et al.
Gemfibrozil is a widely prescribed hypolipidemic agent in humans and a peroxisome proliferator and liver carcinogen in rats. Three-month feed studies of gemfibrozil were conducted by the National Toxicology Program (NTP) in male Harlan Spra...