A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis [0.03%]
基因集合富集分析法比较PPARα敲除小鼠肝和肠的基因表达谱
Kan He,Qishan Wang,Yumei Yang et al.
Kan He et al.
Gene expression profiling of PPARα has been used in several studies, but fewer studies went further to identify the tissue-specific pathways or genes involved in PPARα activation in genome-wide. Here, we employed and applied gene set enri...
Downregulation of the proinflammatory state of circulating mononuclear cells by short-term treatment with pioglitazone in patients with type 2 diabetes mellitus and coronary artery disease [0.03%]
短期使用吡格列酮下调2型糖尿病合并冠心病患者循环单核细胞促炎状态的研究
Andreas Pfützner,Alexander Weise,Elisabeth Pfützner-Riehn et al.
Andreas Pfützner et al.
Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Method...
PPARs and xenobiotic-induced adverse effects: relevance to human health [0.03%]
过氧化物酶体增殖激活受体与外源物质致不良反应的关系及其对人体健康的影响
Christopher Lau,Barbara D Abbott,J Christopher Corton et al.
Christopher Lau et al.
Editorial
PPAR research. 2010:2010:954639. DOI:10.1155/2010/954639 2010
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria [0.03%]
胰岛素增敏剂作为脑疟辅助治疗的依据
Lena Serghides
Lena Serghides
Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused b...
A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [0.03%]
过氧化物酶体增殖激活受体在血吸虫病免疫病理中的作用？
Barrie J Anthony,Jeremy T Allen,Yuesheng S Li et al.
Barrie J Anthony et al.
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation o...
Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism [0.03%]
高亲和力的PPARγ配体通过非PPARγ介导途径抑制人肺成纤维细胞中IL-1β和二氧化硅诱导的炎症介质产生
Christopher M Hogan,Thomas H Thatcher,Ramil E Sapinoro et al.
Christopher M Hogan et al.
Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory ther...
Joshua K Ko,Susanna S Lee,Harry Martin
Joshua K Ko
Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease [0.03%]
异黄酮和PPAR信号传导：心血管、转移和代谢疾病的critical靶点
Rakesh P Patel,Stephen Barnes
Rakesh P Patel
Isoflavone intake through foods and dietary supplements has both health advocates and critics. The latter come from a concern about the estrogenic effects of isoflavones in certain species. However, careful removal of isoflavones and other ...
The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver [0.03%]
肝脏过氧化物酶体3-酮酰辅酶a硫解酶b基因表达受PPARα和HNF4α的双重调控
J Chamouton,F Hansmannel,J A Bonzo et al.
J Chamouton et al.
PPARα and HNF4α are nuclear receptors that control gene transcription by direct binding to specific nucleotide sequences. Using transgenic mice deficient for either PPARα or HNF4α, we show that the expression of the peroxisomal 3-keto-a...
Yaacov Barak,Chih-Hao Lee
Yaacov Barak