Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver [0.03%]
肝核因子4α通过依赖过氧化物酶体增殖激活受体γ的作用诱导I类 scavenger 受体在肝脏中的表达
Yi Zhang,Chen Shen,Ding Ai et al.
Yi Zhang et al.
Hepatic nuclear factor 4α (HNF4α) modulates the transcriptional activation of numerous metabolic genes in liver. In this study, gene-array analysis revealed that HNF4α overexpression increased peroxisome proliferator-activated receptorγ...
Wei Wei,Yihong Wan
Wei Wei
Thiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. However...
Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells [0.03%]
有害ω-6脂质可调节血管细胞中的PPAR-EGR-1交叉信号转导路径
Jia Fei,Carla Cook,Miriah Gillespie et al.
Jia Fei et al.
Atherogenic ω-6 lipids are physiological ligands of peroxisome proliferator-activated receptors (PPARs) and elicit pro- and antiatherogenic responses in vascular cells. The objective of this study was to investigate if ω-6 lipids modulate...
Neuroprotective Mechanisms of PPARδ: Modulation of Oxidative Stress and Inflammatory Processes [0.03%]
PPARδ的神经保护机制：氧化应激和炎症过程的调节
Caroline I Schnegg,Mike E Robbins
Caroline I Schnegg
Peroxisome proliferator-activated receptors (PPARα, δ, and γ) are ligand-activated transcription factors that regulate a wide range of cellular processes, including inflammation, proliferation, differentiation, metabolism, and energy hom...
Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes [0.03%]
罗格列酮诱导小鼠3T3-L1和C3H/10T1/2分化脂肪细胞的线粒体生物发生
James X Rong,Jean-Louis D Klein,Yang Qiu et al.
James X Rong et al.
Growing evidence indicates that PPARγ agonists, including rosiglitazone (RSG), induce adipose mitochondrial biogenesis. By systematically analyzing mitochondrial gene expression in two common murine adipocyte models, the current study aime...
Protective Effects of Peroxisome Proliferator-Activated Receptor-α Agonist, Wy14643, on Hypoxia/Reoxygenation Injury in Primary Rat Hepatocytes [0.03%]
PPAR-α激动剂Wy14643对原代大鼠肝细胞缺血再灌注损伤的保护作用
Ke Chen,Yuan-Hai Li,Si-Qi Xu et al.
Ke Chen et al.
This study investigates the effects and possible mechanism of an agonist of PPARα, Wy14643, on primary hepatocytes subjected to H/R injury in rats. H/R induced a significant increase ALT, AST, MDA in the culture medium and ROS in the hepat...
A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs [0.03%]
从GR和PPARs中透视核受体对炎症的调控作用
Min-Dian Li,Xiaoyong Yang
Min-Dian Li
Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF...
Consequences of PPAR(α) Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids [0.03%]
PPAR(α)失活对谷胱甘肽合成的影响及与膳食脂肪酸的相互作用研究
Najoua Guelzim,Jean-François Huneau,Véronique Mathé et al.
Najoua Guelzim et al.
Glutathione (GSH) derives from cysteine and plays a key role in redox status. GSH synthesis is determined mainly by cysteine availability and γ-glutamate cysteine ligase (γGCL) activity. Because PPARα activation is known to control the m...
Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation [0.03%]
PPARα敲除小鼠中 cardiomyocyte特异性删除PPARβ/δ导致线粒体生物合成和防御受损，但不进一步抑制心肌脂肪酸氧化
Jian Liu,Peiyong Wang,Lan He et al.
Jian Liu et al.
It is well documented that PPARα and PPARβ/δ share overlapping functions in regulating myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte-restricted PPARβ/δ deficiency in mice leads to severe cardiac...
Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours [0.03%]
肝脏PPARs和过氧化物酶体标记物昼夜节律性在饮食限制于每日类昼两小时的喂食条件下的变化规律
Julieta B Rivera-Zavala,Adrián Báez-Ruiz,Mauricio Díaz-Muñoz
Julieta B Rivera-Zavala
Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity ...