Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery [0.03%]
用于肠道药物递送的生物材料衍生碳酸钙纳米粒子
Diane Render,Temesgen Samuel,Howard King et al.
Diane Render et al.
Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug deli...
Antibacterial Activity of Partially Oxidized Ag/Au Nanoparticles against the Oral Pathogen Porphyromonas gingivalis W83 [0.03%]
部分氧化的Ag/Au纳米粒子对口腔病原菌齿垢密螺旋体W83的抗菌活性研究
Megan S Holden,Jason Black,Ainsely Lewis et al.
Megan S Holden et al.
Advances in nanotechnology provide opportunities for the prevention and treatment of periodontal disease. While physicochemical properties of Ag containing nanoparticles (NPs) are known to influence the magnitude of their toxicity, it is th...
Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin [0.03%]
不同卵巢癌细胞系对银纳米颗粒单独作用以及与顺铂联合用药的异质性响应研究
Cale D Fahrenholtz,Jessica Swanner,Maria Ramirez-Perez et al.
Cale D Fahrenholtz et al.
We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell lines (A2780, SKOV3, and OVCAR3). We found that AgNPs were highly cytotoxic toward A2780 and SKOV3 cells but OVCAR3 cells were less sensitive to...
Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophages [0.03%]
银和铁纳米颗粒对巨噬细胞胆固醇摄取的影响
Jonathan H Shannahan,Hari Sowrirajan,Indushekhar Persaud et al.
Jonathan H Shannahan et al.
Macrophages are central to the development of atherosclerosis by absorbing lipids, promoting inflammation, and increasing plaque deposition. Nanoparticles (NPs) are becoming increasingly common in biomedical applications thereby increasing ...
Polymalic Acid Tritryptophan Copolymer Interacts with Lipid Membrane Resulting in Membrane Solubilization [0.03%]
聚.poly-L-丙交酯-乙交酯高分子聚合物与脂质膜相互作用导致膜溶解
Hui Ding,Irving Fox,Rameshwar Patil et al.
Hui Ding et al.
Anionic polymers with membrane permeation functionalities are highly desirable for secure cytoplasmic drug delivery. We have developed tritryptophan containing copolymer (P/WWW) of polymalic acid (PMLA) that permeates membranes by a mechani...
Effect on Growth, Photosynthesis, and Oxidative Stress of Single Walled Carbon Nanotubes Exposure to Marine Alga Dunaliella tertiolecta [0.03%]
单壁碳纳米管对海洋藻类杜氏藻(Dunaliella tertiolecta)生长、光合作用及氧化应激的影响
Megha Thakkar,Somenath Mitra,Liping Wei
Megha Thakkar
Single walled carbon nanotubes were carboxylated by microwave assisted acid oxidation (f-SWCNTs) and examined for their ecotoxicity on marine alga chlorophyte Dunaliella tertiolecta. Toxicity was evaluated based on growth, photosynthetic ac...
Effects of multiwalled carbon nanotube surface modification and purification on bovine serum albumin binding and biological responses [0.03%]
表面改性处理对多壁碳纳米管与牛血清白蛋白结合及生物反应的影响
Wei Bai,Zheqiong Wu,Somenath Mitra et al.
Wei Bai et al.
The potential diagnostic and therapeutic applications such as drug delivery of multi-walled carbon nanotubes (MWCNTs) are being increasingly explored due to their unique mechanical, chemical and biological properties. Carboxylation of MWCNT...
Xiaojiao Yu,Ian Trase,Muqing Ren et al.
Xiaojiao Yu et al.
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to bet...
Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats [0.03%]
气管内注入硅纳米线后大鼠肺毒性、分布及清除研究
Jenny R Roberts,Robert R Mercer,Rebecca S Chapman et al.
Jenny R Roberts et al.
Silicon nanowires (Si NWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were in...
Bioaccumulation, Sub-acute Toxicity, and Tissue Distribution of Engineered Titanium Dioxide (TiO2) Nanoparticles in Goldfish (Carassius auratus) [0.03%]
金鱼（Carassius auratus）对人工合成二氧化钛纳米粒子的生物蓄积、亚急性毒性和组织分布研究
Mehmet Ates,Veysel Demir,Ragip Adiguzel et al.
Mehmet Ates et al.
The increased use of nano-sized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sub-lethal effects of exposu...