Identification and analgesic activity study of analgesic protein Ⅶ-2 from Naja naja atra venom [0.03%]
从黑曼蛇毒液中鉴定并研究镇痛蛋白VII-2及其镇痛活性
Yao Sun,Gen-Bao Zhang,Shu Li et al.
Yao Sun et al.
Background: Acid-sensing ion channel 1a (ASIC1a) plays a critical role in physiological and pathological processes. To further elucidate the biological functions of ASICs and their relationships with disease occurrence an...
Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience [0.03%]
肽毒素作用于电压门控离子通道的电生理评价：以中美和南美经验为中心的理论和方法综述性回顾
Jessica Rojas-Palomino,Alejandro Gómez-Restrepo,Cristian Salinas-Restrepo et al.
Jessica Rojas-Palomino et al.
The effect of peptide toxins on voltage-gated ion channels can be reliably assessed using electrophysiological assays, such as the patch-clamp technique. However, much of the toxinological research done in Central and South America aims at ...
Cupiennius spiders (Trechaleidae) from southern Mexico: DNA barcoding, venomics, and biological effect [0.03%]
墨西哥南部的Trechaleidae genus Cupiennius蜘蛛：DNA条形码、毒液组学和生物效应
Montserrat Padilla-Villavicencio,Gerardo Corzo,Karina Guillén-Navarro et al.
Montserrat Padilla-Villavicencio et al.
Background: Members of the genus Cupiennius Simon, 1891 are categorized as wandering spiders and are part of the family Trechaleidae. The genomics and proteomics of Cupiennius spiders from North America remain uncharacter...
Protective effects of mesenchymal stromal cell-derived secretome on dermonecrosis induced in rabbits by Loxosceles intermedia spider venom [0.03%]
兔Loxosceles intermedia spiders毒液诱导的皮肤坏死模型中，间充质基质细胞分泌组的保护作用
Gabriela Marques Rodrigues,Mara Elvira de Almeida,Sóstenes Apolo Correia Marcelino et al.
Gabriela Marques Rodrigues et al.
Background: Loxoscelism refers to a set of clinical manifestations caused by the bite of spiders from the Loxosceles genus. The classic clinical symptoms are characterized by an intense inflammatory reaction at the bite s...
An improved high-performance liquid chromatography (HPLC) method for detection of variations in the hydroxyproline content of tissue homogenates from Paracoccidioides brasiliensis-infected mice [0.03%]
一种改良的高效液相色谱法检测巴西芽生菌感染小鼠组织匀浆中羟脯氨酸含量变化
Magnus Ake Gidlund,Raphael Fagnani Sanchez Molina,Eva Burger
Magnus Ake Gidlund
Background: Paracoccidioidomycosis (PCM) is a severe granulomatous disease. The hallmark of this mycosis is fibrin degradation and granuloma formation as a result of a wound-healing process in the context of excessive inf...
Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway [0.03%]
斑条森林蛇含固有神经生长因子信号肽的毒液片段通过激活NGF信号通路保护多巴胺能神经元细胞免受MPP+毒性损伤
Carolina Petri Bernardes,Ernesto Lopes Pinheiro,Isabela Gobbo Ferreira et al.
Carolina Petri Bernardes et al.
Background: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. There is no effective treatment for neurodegenerative diseases. Snake venoms are a cocktail of proteins and peptides with great ...
Acute phase reactions in Daboia siamensis venom and fraction-induced acute kidney injury: the role of oxidative stress and inflammatory pathways in in vivo rabbit and ex vivo rabbit kidney models [0.03%]
从短尾锯鳞蛇毒及其组分诱导的急性肾损伤中探究急性期反应：体内兔子和体外兔子肾脏模型中的氧化应激及炎症途径的作用
Narongsak Chaiyabutr,Jureeporn Noiprom,Kanyanat Promruangreang et al.
Narongsak Chaiyabutr et al.
Background: This study examines the direct nephrotoxic effects of Daboia siamensis venom (RVV) and venom fractions in in vivo and isolated perfused kidneys (IPK) to understand the role of inflammation pathways and suscept...
Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration [0.03%]
延迟进行面神经修复及其对神经和肌肉再生的负面影响
Cleuber Rodrigo de Souza Bueno,Daniela Vieira Buchaim,Benedito Barraviera et al.
Cleuber Rodrigo de Souza Bueno et al.
Background: In this experimental protocol, we evaluated the immediate and delayed repair of the buccal branch of the facial nerve (BBFN) with heterologous fibrin biopolymer (HFB) as a coaptation medium and the use of phot...
Effects of local and systemic treatment with human natural killer-1 mimetic peptide (HNK-1) after ventral root avulsion and reimplantation in mice [0.03%]
mimic肽(HNK-1)治疗背根切断再植入小鼠的局部及全身效果研究
Natalia Scanavachia da Silva,Julia Lombardi,Frank Kirchhoff et al.
Natalia Scanavachia da Silva et al.
Background: Spinal ventral root injuries generate significant motoneuron degeneration, which hinders full functional recovery. The poor prognosis of functional recovery can be attributed to the use or combination of diffe...
Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review [0.03%]
异源性纤维蛋白生物聚合物在外周神经修复中的新兴作用：系统综述
Kevin Silva Muller,Felipe Cantore Tibúrcio,Rui Seabra Ferreira et al.
Kevin Silva Muller et al.
Nerve injuries present a substantial challenge within the medical domain due to their prevalent occurrence and significant impact. In nerve injuries, a range of physiopathological and metabolic responses come into play to stabilize and repa...