Development and validation of a spectrophotometric method for the quantification of total bufadienolides in samples of toad glandular secretions [0.03%]
一种蟾毒类bufadienolides总量测定的方法开发及验证
Elcio Daniel Sousa Barros,Evaldo Dos Santos Monção,Mariana Helena Chaves et al.
Elcio Daniel Sousa Barros et al.
Background: Bufadienolides are the main secondary metabolites found in the paratoid gland secretions (PGS) of toads of the Bufonidae family. These compounds are considered the main bioactive components of PGS. The aim of ...
A comprehensive overview of fish envenomation and venom toxicity in Brazil [0.03%]
巴西鱼类毒刺伤的全面概述及毒素毒性分析
Mônica Lopes-Ferreira,Felipe Justiniano Pinto,Yasmin Stefanie Oliveira Costa et al.
Mônica Lopes-Ferreira et al.
Background: Brazilian waters are home to various venomous fish species, each with its unique venom composition. Although common, envenomation cases are largely underreported, leading to a lack of public health policies fo...
Epitope-based antibody development against metalloproteinases and phospholipases A2 from Deinagkistrodon acutus venom [0.03%]
基于表位的金属蛋白酶和毒液中磷脂酶抗体制备
Haiting Zhu,Yuexin Pan,Zhiyuan Tai et al.
Haiting Zhu et al.
Background: Deinagkistrodon acutus, or the hundred-pace snake, poses severe health risks due to its venom. Envenomation by this snake leads to complications such as hemorrhage, edema, and coagulopathy. Traditional antiven...
Jonas Gama Martins,Pedro Pereira de Oliveira Pardal,Antonio Domingos Brescovit et al.
Jonas Gama Martins et al.
Background: Spiders of medical importance in the Amazon region belong to the genera Phoneutria, Loxosceles and Latrodectus. Natural history data show that Phoneutria spp. occur in both periodically flooded forest areas (i...
Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models [0.03%]
蜂毒肽通过二维和三维模型抑制成骨肉瘤细胞系的增殖、迁移和侵袭作用
Giovana Pedro,Felipe César da Silva Brasileiro,Rui Seabra Ferreira Jr et al.
Giovana Pedro et al.
Background: Osteosarcoma is the most common primary bone tumor in humans. It is a locally aggressive tumor at the primary site, with metastasis being the main cause of death in patients. Studies on dogs have gained promin...
Molecular interaction assays in silico of crotapotin from Crotalus durissus terrificus against the molecular target trypanothione reductase from Leishmania braziliensis [0.03%]
秘鲁烙铁头三步蛇中的Crotapotin与巴西布氏利什曼原虫的分子靶点-辅酶A还原酶的计算机分子对接试验
Jamile Mariano Macedo,Mateus Farias Souza,Anderson Maciel Lima et al.
Jamile Mariano Macedo et al.
Background: Leishmaniasis is a neglected disease that mainly affects impoverished populations and receives limited attention from governments and research institutions. Current treatments are based on antimonial therapies...
Influence of envenomation timing on peripheral immune and oxidative responses in experimental scorpion envenomation [0.03%]
中毒时间对实验性蝎子蜇伤外周免疫和氧化反应的影响
Fares Daachi,Sonia Adi-Bessalem,Amal Megdad-Lamraoui et al.
Fares Daachi et al.
Background: Scorpion envenomation poses a significant health threat in endemic regions, eliciting complex immune responses in affected individuals. Recent research suggests that the timing of envenomation - whether it occ...
Physiological responses of the monocled cobra (Naja kaouthia Lesson, 1831) including venom production, to high ambient temperature exposure [0.03%]
环纹眼镜蛇(Naja kaouthia Lesson, 1831)对高温暴露的生理反应，包括毒液产生反应
Taksa Vasaruchapong,Narongsak Chaiyabutr,Thanida Nampimoon et al.
Taksa Vasaruchapong et al.
Background: Temperature regulation is essentially important for survival of poikilotherms such as snakes. Body temperature is regulated by snakes through behavioral and physiological responses. The global-warming crisis, ...
Cystatin from Austrelaps superbus snake venom as a model for identifying potential inhibitors of Trypanosoma cruzi cruzain [0.03%]
Austrelaps superbus蛇毒中的囊泡蛋白酶抑制剂作为鉴定克氏锥虫裂解酶潜在抑制剂的模型
Jorge Javier Alfonso Ruiz Díaz,Ana Fidelina Gómez Garay,Anderson Makoto Kayano et al.
Jorge Javier Alfonso Ruiz Díaz et al.
Background: Chagas disease (CD), caused by Trypanosoma cruzi, affects approximately seven million individuals worldwide, with the highest number of cases in Latin America. CD has two phases, of which the chronic phase is ...
Rhopalurus junceus scorpion venom induces G2/M cell cycle arrest and apoptotic cell death in human non-small lung cancer cell lines [0.03%]
东亚狭头蝎毒通过细胞周期阻滞和凋亡诱导人非小细胞肺癌细胞死亡
Alexis Díaz-García,Ángel Garrido,Jenny Laura Ruiz-Fuentes et al.
Alexis Díaz-García et al.
Background: Non-small cell lung cancers (NSCLC) represent the primary cause of cancer-related deaths worldwide. Rhopalurus junceus venom has been shown to exert cytotoxic effects against a panel of epithelial cancer cells...