Second-generation pterocarpanquinones: synthesis and antileishmanial activity [0.03%]
二代pterocarpanquinones：合成和抗利什曼病活性
Viviane Dos Santos Faiões,Lívia C R M da Frota,Edézio Ferreira Cunha-Junior et al.
Viviane Dos Santos Faiões et al.
Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Viscer...
Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom [0.03%]
矛头腹细沟掌毒素磷脂酶A2的细胞毒性和炎症反应效应
Rafhaella C A Cedro,Danilo L Menaldo,Tássia R Costa et al.
Rafhaella C A Cedro et al.
Background: Snake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This work aimed at the isolation and functional characte...
Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom [0.03%]
一条秘鲁烙铁头蛇(Lachesis muta rhombeata)蛇毒中一种新的金属蛋白酶的分离纯化及酶学性质表征
Francielle Almeida Cordeiro,Bárbara Marques Coutinho,Gisele Adriano Wiezel et al.
Francielle Almeida Cordeiro et al.
Background: Lachesis muta rhombeata (Lmr) is the largest venomous snake in Latin America and its venom contains mainly enzymatic components, such as serine and metalloproteases, L-amino acid oxidase and phospholipases A2....
Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model [0.03%]
合成肽LyeTx I b眼内注射安全且可防止鸡胚尿囊膜模型中的新生血管生成
Flavia Rodrigues da Silva,Mayara Rodrigues Brandão de Paiva,Lays Fernanda Nunes Dourado et al.
Flavia Rodrigues da Silva et al.
Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion chan...
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study [0.03%]
盐酸舍曲林抗查加斯病原虫疗效的体外和分子模拟研究
Daiane Dias Ferreira,Juliana Tonini Mesquita,Thais Alves da Costa Silva et al.
Daiane Dias Ferreira et al.
Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease. Methods: ...
Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach [0.03%]
抗心律失常药物胺碘酮对利什曼原虫（L.）婴儿体的活性：一种体内和体外的方法
Erika G Pinto,Andre G Tempone
Erika G Pinto
Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. ...
Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom [0.03%]
矛头竹叶青蛇毒中一种非RGD型disintegrin的细胞迁移抑制作用
Isadora Sousa de Oliveira,Rafaella Varzoni Manzini,Isabela Gobbo Ferreira et al.
Isadora Sousa de Oliveira et al.
Background: In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can i...
Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity [0.03%]
拉尾树属羽叶拉尾树的树枝中分离得到的新木脂素具有体外抗利什曼病活性
Simone S Grecco,Thais A Costa-Silva,Fernanda S Sousa et al.
Simone S Grecco et al.
Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds ...
4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents [0.03%]
4-苯基-1,3-噻唑-2-胺类抗利什曼病药物的新骨架结构
Carina Agostinho Rodrigues,Paloma Freire Dos Santos,Marcela Oliveira Legramanti da Costa et al.
Carina Agostinho Rodrigues et al.
Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leis...
Impact of autologous whole blood administration upon experimental mouse models of acute Trypanosoma cruzi infection [0.03%]
自身全血输注对急性克氏锥虫感染小鼠模型的影响
Beatriz Philot Pavão,Kelly Cristina Demarque,Marcos Meuser Batista et al.
Beatriz Philot Pavão et al.
Background: Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias. ...