Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins [0.03%]
锯纹食土蚁毒液组分蛋白组研究发现新的酶和毒素
Fernanda Gobbi Amorim,Heloisa Tavoni Longhim,Camila Takeno Cologna et al.
Fernanda Gobbi Amorim et al.
Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several compounds with biotechnological and therapeutical potentials, which highlights the importance of the identification and characterization of th...
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression [0.03%]
作用于Kv1.3通道的蝎毒与免疫抑制作用的新见解
Isadora S Oliveira,Isabela G Ferreira,Gabriel M Alexandre-Silva et al.
Isadora S Oliveira et al.
Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium chan...
BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells [0.03%]
BjussuLAAO-II诱导单一培养/共培养的HepG2细胞的细胞毒性并改变细胞周期基因的DNA甲基化
Ana Rita Thomazela Machado,Alexandre Ferro Aissa,Diego Luis Ribeiro et al.
Ana Rita Thomazela Machado et al.
Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) ...
Identification of a pore-forming protein from sea anemone Anthopleura dowii Verrill (1869) venom by mass spectrometry [0.03%]
质谱鉴定出一种来源于六角海葵Anthopleura dowii Verrill (1869) 毒液的孔道形成蛋白
Santos Ramírez-Carreto,Erick I Pérez-García,Sandra I Salazar-García et al.
Santos Ramírez-Carreto et al.
Background: Pore-forming proteins (PFP) are a class of toxins abundant in the venom of sea anemones. Owing to their ability to recognize and permeabilize cell membranes, pore-forming proteins have medical potential in can...
Functional and biological insights of rCollinein-1, a recombinant serine protease from Crotalus durissus collilineatus [0.03%]
来自Crotalus durissus collilineatus的重组丝氨酸蛋白酶rCollinein-1的功能和生物学见解
Johara Boldrini-França,Ernesto Lopes Pinheiro-Junior,Eliane Candiani Arantes
Johara Boldrini-França
Background: The prevalent class of snake venom serine proteases (SVSP) in Viperidae venoms is the thrombin-like enzymes, which, similarly to human thrombin, convert fibrinogen into insoluble fibrin monomers. However, thro...
Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase [0.03%]
Lachesis muta rhombeata毒液的亚蛋白组及新型蛇毒丝氨酸蛋白酶LmrSP-4初步研究
Gisele A Wiezel,Karla Cf Bordon,Ronivaldo R Silva et al.
Gisele A Wiezel et al.
Background: Lachesis muta rhombeata is one of the venomous snakes of medical importance in Brazil whose envenoming is characterized by local and systemic effects which may produce even shock and death. Its venom is mainly...
A lung image reconstruction from computed radiography images as a tool to tuberculosis treatment control [0.03%]
基于计算机放射断层摄影图像的肺部影像重建在结核病治疗管控中的作用研究
Marcela de Oliveira,Sergio Barbosa Duarte,Guilherme Giacomini et al.
Marcela de Oliveira et al.
Background: Background: Tuberculosis (TB) is an infectious lung disease with high worldwide incidence that severely compromises the quality of life in affected individuals. Clinical tests are currently employed to monitor...
Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice [0.03%]
快中子照射产生的抗imonial在感染利什曼原虫的BALB/c小鼠体内的药代动力学研究
Samanta Etel Treiger Borborema,João Alberto Osso,Heitor Franco de Andrade et al.
Samanta Etel Treiger Borborema et al.
Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases....
Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes [0.03%]
硝基杂环化合物使利什曼原虫产生类似凋亡的效果
Daiane Barros Dias Mendonça,Renata Ellen Costa Silva,Fanny Palace-Berl et al.
Daiane Barros Dias Mendonça et al.
Background: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal a...
Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases [0.03%]
被忽视的热带原生动物病纳米颗粒药物输送系统治疗
Greta Volpedo,Lourena Costa,Nathan Ryan et al.
Greta Volpedo et al.
Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosom...