The WHO strategy for prevention and control of snakebite envenoming: a sub-Saharan Africa plan [0.03%]
世卫组织防范和控制蛇咬伤中毒战略：撒哈南非洲计划
Jean-Philippe Chippaux,Achille Massougbodji,Abdulrazaq G Habib
Jean-Philippe Chippaux
Snakebite is a critical public health issue in tropical countries, particularly in Africa, where 20% of snakebites globally occur. In 2017, the WHO added snakebite envenoming to the category A of neglected tropical diseases. In 2019, thanks...
Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review [0.03%]
一种独特的异种纤维素生物聚合物的止血、粘合、封闭、支架和药物输送性能：系统性综述
Daniela Vieira Buchaim,Claudia Vilalva Cassaro,João Vitor Tadashi Cosin Shindo et al.
Daniela Vieira Buchaim et al.
Fibrin biopolymers, previously referred as "fibrin glue" or "fibrin sealants", are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become wide...
Heterologous expression and mutagenesis of recombinant Vespa affinis hyaluronidase protein (rVesA2) [0.03%]
异种表达和突变重组 Vespa affinis 透明质酸酶蛋白(rVesA2)
Prapenpuksiri Rungsa,Piyapon Janpan,Yutthakan Saengkun et al.
Prapenpuksiri Rungsa et al.
Background: Crude venom of the banded tiger waspVespa affinis contains a variety of enzymes including hyaluronidases, commonly known as spreading factors. ...
Samsum ant venom modulates the immune response and redox status at the acute toxic dose in vivo [0.03%]
沙库姆蚁毒液调节急性中毒剂量下体内免疫反应和氧化还原状态
Hossam Ebaid,Bahaa Abdel-Salam,Ibrahim Alhazza et al.
Hossam Ebaid et al.
Background: Ant venoms express surface molecules that participate in antigen presentation involving pro- and anti-inflammatory cytokines. This work aims to investigate the expression of MHC-II, CD80 and CD86 on the polymo...
Fibrin biopolymer as scaffold candidate to treat bone defects in rats [0.03%]
纤维蛋白生物聚合物作为治疗大鼠骨缺损的支架候选材料
Claudia Vilalva Cassaro,Luis Antonio Justulin Jr,Patrícia Rodrigues de Lima et al.
Claudia Vilalva Cassaro et al.
Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in t...
Cytotoxic effects of Pseudocerastes persicus venom and its HPLC fractions on lung cancer cells [0.03%]
Pseudocerastes persicus毒液及其HPLC分组对肺癌细胞的细胞毒性作用
Benyamin Shahbazi,Zahra Salehi Najafabadi,Hamidreza Goudarzi et al.
Benyamin Shahbazi et al.
Background: Several studies have pointed out that certain snake venoms contain compounds presenting cytotoxic activities that selectively interfere with cancer cell metabolism. In this study, Pseudocerastes persicus venom...
Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against Zika virus infection? [0.03%]
寨卡病毒蛋白的原子结构：结构生物学如何帮助我们了解并研发预防和治疗寨卡病毒感染的疫苗和药物？
Ana Paula Valente,Adolfo Henrique Moraes
Ana Paula Valente
In Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barré syndrome in adults. Rece...
Protein identification from the parotoid macrogland secretion of Duttaphrynus melanostictus [0.03%]
孟加拉毒隐裂蛇下颌大毒腺蛋白质组学研究
Douglas Oscar Ceolin Mariano,Marcela Di Giacomo Messias,Patrick Jack Spencer et al.
Douglas Oscar Ceolin Mariano et al.
Background: Bufonid parotoid macrogland secretion contains several low molecular mass molecules, such as alkaloids and steroids. Nevertheless, its protein content is poorly understood. Herein, we applied a sample preparat...
Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system [0.03%]
Phoneutria nigriventer蜘蛛毒液中的肽PnTx4(5-5)的抗痛觉作用及谷氨酸能系统的参与作用研究
Camila Franco Batista Oliveira,Daniela Pereira Alves,Bruna Luiza Emerich et al.
Camila Franco Batista Oliveira et al.
Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparen...
Antileishmanial activity and immunomodulatory effect of seco subamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae) [0.03%]
来自Nectandra oppositifolia（壳斗科）的丁内酯类成分seco subamolide的抗利什曼病活性及免疫调节作用
Thais A da Costa-Silva,Geanne A Alves Conserva,Andrés J Galisteo Jr et al.
Thais A da Costa-Silva et al.
Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural produc...