MS/MS analysis of four scorpion venoms from Colombia: a descriptive approach [0.03%]
描述性分析四种哥伦比亚溶组织内阿米巴毒液中的肽和蛋白质
Sebastian Estrada-Gómez,Leidy Johana Vargas-Muñoz,Monica Maria Saldarriaga-Córdoba et al.
Sebastian Estrada-Gómez et al.
Background: Scorpions are widely known for the neurotoxic effects of their venoms, which contain peptides affecting ionic channels. Although Colombia is recognized for its scorpion diversity, only a few studies are availa...
Effects of climate variables on the incidence of scorpion stings in Iran for five years [0.03%]
气候因素对伊朗五年人被蝎子蜇伤的影响研究
Ahmad Ghorbani,Behzad Mansouri,Masoumeh Baradaran
Ahmad Ghorbani
Background: Although scorpionism is recorded worldwide, some regions such as Iran present a higher incidence. Due to the great prevalence of scorpion stings in Khuzestan province, southwestern Iran, the present study exam...
Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro [0.03%]
神经毒素化合物作为潜在的治疗神经退行性疾病的先导：体内乙酰胆碱酯酶和β-分泌酶抑制活性研究
Simon Miguel M Lopez,Jeremey S Aguilar,Jerene Bashia B Fernandez et al.
Simon Miguel M Lopez et al.
Background: Spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (AChE) that regulate...
Effects of venoms on neutrophil respiratory burst: a major inflammatory function [0.03%]
毒液对中性粒细胞呼吸爆发的影响：一个主要的炎症功能
Jamel El-Benna,Margarita Hurtado-Nedelec,Marie-Anne Gougerot-Pocidalo et al.
Jamel El-Benna et al.
Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due...
A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents [0.03%]
一种新颖的富含脯氨酸M超家族芋螺毒素可同时影响钠、钾和钙电流
Manyi Yang,Yubin Li,Longfei Liu et al.
Manyi Yang et al.
Background: Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors. There have been reports of a conotoxin...
Novel neuroprotective peptides in the venom of the solitary scoliid wasp Scolia decorata ventralis [0.03%]
孤纹泥蜂(Scolia decorata ventralis)毒液中的新型神经保护肽
Carlos Alberto-Silva,Fernanda Calheta Vieira Portaro,Roberto Tadashi Kodama et al.
Carlos Alberto-Silva et al.
Background: Solitary wasp venoms may be a rich source of neuroactive substances, since their venoms are used for paralyzing preys. We have been exploring bioactive constituents of solitary wasp venoms and, in this study, ...
Glycosylation of β1 subunit plays a pivotal role in the toxin sensitivity and activation of BK channels [0.03%]
β1亚单位糖基化在大电导钾通道的毒物敏感性和激活过程中发挥关键作用
Xiaoli Wang,Qian Xiao,Yudan Zhu et al.
Xiaoli Wang et al.
Background: The accessory β1 subunits, regulating the pharmacological and biophysical properties of BK channels, always undergo post-translational modifications, especially glycosylation. To date, it remains elusive whet...
Vector saliva controlled inflammatory response of the host may represent the Achilles heel during pathogen transmission [0.03%]
唾液介导的宿主炎症反应可能是在病原体传播过程中的阿喀琉斯之踵
Claudia Demarta-Gatsi,Salah Mécheri
Claudia Demarta-Gatsi
Infection with vector-borne pathogens starts with the inoculation of these pathogens during blood feeding. In endemic regions, the population is regularly bitten by naive vectors, implicating a permanent stimulation of the immune system by ...
Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell's viper (Daboia russelii) venoms [0.03%]
斯里兰卡和印度烙铁头蛇（Daboia russelii）毒液的蛋白质组学、毒性及抗蛇毒血清中和试验
Tasnim Faisal,Kae Yi Tan,Nget Hong Tan et al.
Tasnim Faisal et al.
Background: The western Russell's viper (Daboia russelii) is widely distributed in South Asia, and geographical venom variation is anticipated among distant populations. Antivenoms used for Russell's viper envenomation ar...
Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [0.03%]
辐照破伤风毒素的酶活性研究
Giselle Pacifico Sartori,Andréa da Costa,Fernanda Lúcio Dos Santos Macarini et al.
Giselle Pacifico Sartori et al.
Background: Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination. The vaccine is produced by inactiva...