De novo venom gland transcriptomics of Calliophis bivirgata flaviceps: uncovering the complexity of toxins from the Malayan blue coral snake [0.03%]
马来蓝珊瑚蛇Calliophis bivirgata flaviceps毒腺的从头转录组分析：揭开毒素的复杂性
Praneetha Palasuberniam,Kae Yi Tan,Choo Hock Tan
Praneetha Palasuberniam
Background: The Malayan blue coral snake, Calliophis bivirgata flaviceps, is a medically important venomous snake in Southeast Asia. However, the complexity and diversity of its venom genes remain little explored. ...
Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps [0.03%]
巴西亚马逊地区的具有医学意义的蝎子种类：一篇综述以识别知识空白
Jonas Gama Martins,Gabrielle Cristina Santos,Rudi Emerson de Lima Procópio et al.
Jonas Gama Martins et al.
Scorpionism is a relevant medical condition in Brazil. It is responsible for most accidents involving venomous animals in the country, which leads to severe symptoms that can evolve to death. In recent years, an increase of almost 50% in th...
Armed stem to stinger: a review of the ecological roles of scorpion weapons [0.03%]
武装毒刺：对蝎子武器的生态作用进行回顾
Yuri Simone,Arie van der Meijden
Yuri Simone
Scorpions possess two systems of weapons: the pincers (chelae) and the stinger (telson). These are placed on anatomically and developmentally well separated parts of the body, that is, the oral appendages and at the end of the body axis. Th...
Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice [0.03%]
等效剂量图分析揭示了Phα1β重组毒素与吗啡在C57BL/6J小鼠癌症疼痛模型中的协同镇痛作用
Caio Tavares Aoki,Rodrigo Andrade Moura,Luana Assis Ferreira et al.
Caio Tavares Aoki et al.
Background: Phoneutria nigriventer venom contains Phα1β. This toxin and its recombinant form have a remarkable analgesic potential that is associated with blockage of voltage-gated calcium channels and TRPA1 receptors. ...
Naila Albertina de Oliveira,Simone Cristina Cardoso,Dulce Aparecida Barbosa et al.
Naila Albertina de Oliveira et al.
Either bites or stings of venomous animals comprise relevant public health problems in tropical countries. Acute kidney injury (AKI) induced by animal toxins is related to worse prognostic and outcomes. Being one the most important pathways...
Through DNA sensors and hidden mitochondrial effects of SARS-CoV-2 [0.03%]
通过DNA传感器和SARS-CoV-2隐蔽的线粒体效应
Vitor Pedro Targhetta,Mariana Abrantes Amaral,Niels Olsen Saraiva Camara
Vitor Pedro Targhetta
The COVID-19 pandemic brought attention to studies about viral infections and their impact on the cell machinery. SARS-CoV-2, for example, invades the host cells by ACE2 interaction and possibly hijacks the mitochondria. To better understan...
P-I metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis [0.03%]
从Bothrops毒蛇中鉴定出的金属蛋白酶和氨基酸氧化酶的抗血管生成作用
Shreesha K Bhat,Manjunath B Joshi,Sampara Vasishta et al.
Shreesha K Bhat et al.
Background: Snake venoms are composed of pharmacologically active proteins that are evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as a source of bioactive molecules in treating n...
Emídio Beraldo,Guilherme Rabelo Coelho,Juliana Mozer Sciani et al.
Emídio Beraldo et al.
Background: Naja mandalayensis is a spitting cobra from Myanmar. To the best of our knowledge, no studies on this venom composition have been conducted so far. On the other hand, few envenomation descriptions state that i...
Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV [0.03%]
SARS-CoV-2、HIV、HCV和HBV所致人类病毒性疾病中的炎症与肾脏损伤
Gustavo Ferreira da Mata,Danilo Euclides Fernandes,Eduardo de Paiva Luciano et al.
Gustavo Ferreira da Mata et al.
Inflammation is closely related to renal diseases. This is particularly true for renal diseases caused by infections as in viral diseases. In this review, we highlight the inflammatory mechanisms that underlie kidney dysfunction in SARS-CoV...
Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins? [0.03%]
棕色蜘蛛毒液毒素有什么功能？_ASTACINS、丝氨酸蛋白酶、透明质酸酶、过敏原、TCTP、丝氨酸蛋白酶抑制剂和结节蛋白的功能是什么？
Luiza Helena Gremski,Fernando Hitomi Matsubara,Hanna Câmara da Justa et al.
Luiza Helena Gremski et al.
Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition that often includes a threatening necrotic skin lesion near the bite site along with a remarkable inflammatory response. Systemic disorders such as he...