Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy [0.03%]
炎症、肾素血管紧张素醛固酮和激肽系统的相互作用：COVID-19治疗的建议方案
Lilian Caroline Gonçalves Oliveira,Nayara Azinheira Nobrega Cruz,Bruna Ricelli et al.
Lilian Caroline Gonçalves Oliveira et al.
Coronavirus disease 2019 (COVID-19) is a rapid-spread infectious disease caused by the SARS-CoV-2 virus, which can culminate in the renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) systems imbalance, and in serious consequenc...
Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores [0.03%]
亚马逊蝎子和蝎毒危害：整合毒素学、临床与系统发生学数据以应对世界上生物多样性最丰富雨林地区的人类健康危机
Adolfo Borges,Matthew R Graham,Denise M Cândido et al.
Adolfo Borges et al.
Venom from Amazonian scorpions of the genus Tityus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneri...
Virucidal activity of oriental hornet Vespa orientalis venom against hepatitis C virus [0.03%]
东方胡蜂毒液对丙型肝炎病毒的抗病毒作用
Moustafa Sarhan,Alaa M H El-Bitar,Amaal Mohammadein et al.
Moustafa Sarhan et al.
Background: Hepatitis C virus (HCV) infection is a major worldwide health problem that can cause liver fibrosis and hepatocellular carcinoma (HCC). The clinical treatment of HCV infection mainly relies on the use of direc...
Keven Wender Rodrigues Macedo,Lucas Jeferson de Lima Costa,Jéssica Oliveira de Souza et al.
Keven Wender Rodrigues Macedo et al.
The Theraphosidae family includes the largest number of species of the Mygalomorphae infraorder, with hundreds of species currently catalogued. However, there is a huge lack on physiologic and even ecologic information available, especially...
Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways [0.03%]
Phα1β毒素的镇痛作用：涉及疼痛通路的作用机制综述
Juliana Figueira da Silva,Nancy Scardua Binda,Elizete Maria Rita Pereira et al.
Juliana Figueira da Silva et al.
Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type HVA calcium channels (NVACC) and an analgesic effect in seve...
Ariane Teixeira Dos Santos,Gabriela Silva Cruz,Gandhi Rádis Baptista
Ariane Teixeira Dos Santos
Peptides obtained from different animal species have gained importance recently due to research that aims to develop biopharmaceuticals with therapeutic potential. In this sense, arthropod venoms have drawn attention, not only because of th...
Widow spiders in the New World: a review on Latrodectus Walckenaer, 1805 (Theridiidae) and latrodectism in the Americas [0.03%]
新大陆上的寡妇蜘蛛：对美洲的Latrodectus Walckenaer（1805）(Theridiidae)及其毒液引起的latrodectism的综述
Marjolly Brigido Caruso,Pedro Santana Sales Lauria,Claudio Maurício Vieira de Souza et al.
Marjolly Brigido Caruso et al.
Humankind has always been fascinated by venomous animals, as their toxic substances have transformed them into symbols of power and mystery. Over the centuries, researchers have been trying to understand animal venoms, unveiling intricate m...
Exploring the five-paced viper (Deinagkistrodon acutus) venom proteome by integrating a combinatorial peptide ligand library approach with shotgun LC-MS/MS [0.03%]
五步蛇(Deinagkistrodon acutus)毒液蛋白质组的探索：结合组合肽配体库方法与全谱LC-MS / MS分析
Xuekui Nie,Qiyi He,Bin Zhou et al.
Xuekui Nie et al.
Background: Snake venoms are complex mixtures of toxic proteins or peptides encoded by various gene families that function synergistically to incapacitate prey. In the present study, in order to unravel the proteomic repe...
Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications [0.03%]
红海彩带宫螺毒液的蛋白质组分析揭示了潜在的生物应用
Maged M A Fouda,Mohammed Abdel-Wahab,Amal Mohammadien et al.
Maged M A Fouda et al.
Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools a...
Inflammation: improving understanding to prevent or ameliorate kidney diseases [0.03%]
炎症：增进理解以预防或缓解肾脏疾病
Sheila Marques Fernandes,Mirian Watanabe,Maria de Fátima Fernandes Vattimo
Sheila Marques Fernandes
Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammatio...